Results 101 to 110 of about 3,546,996 (310)
The European Pillar of Social Rights. Implementation and effects in the EU Member States [PDF]
Global Economic Observer, 2020 The article focuses on the research into the European Pillar of Social Rights, as well as the challenges of applying the basic principles in the Member States, in order to identify the best measures for their implementation in the European Community ...
ALINA LIGIA DUMITRESCU
doaj
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Human Rights Accountability Through Treaty Bodies: Examining Human Rights Treaty Monitoring for Water and Sanitation [PDF]
, 2015 Framing scholarship on human rights accountability through treaty bodies, this article examines the water and sanitation content of state human rights reporting to the United Nations Committee on Economic, Social and Cultural Rights.
Kim, Yuna, Meier, Benjamin Mason
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Review of Economic Performance and Social Progress 2001: The Longest Decade: Canada in the 1990s [PDF]
In this chapter, Lars Osberg has the daunting task of examining the conceptual issues involved in defining and measuring social progress. As he highlights in his introduction, while much had been made of the fact that Canada in 2000 earned first place in
Andrew Sharpe, Executive Director +3 more
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Trade Unions and Human Rights [PDF]
, 2008 [Excerpt] In the 1990s the parallel but separate tracks of the labor movement and the human rights movement began to converge. This chapter examines how trade union advocates adopted human rights analyses and arguments in their work, and human rights ...
Compa, Lance
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Revista de Derecho Político, 2011 En este trabajo se abordan los problemas relativos al derecho a la vivienda como derecho social reconocido en diversos textos normativos, especialmente la Carta Social Europea.
Giovanni Guiglia
doaj +1 more source
Rights, social policy and reproductive wellbeing: the Vietnam situation [PDF]
, 2001 Wellbeing Rights and Reproduction Research Paper ...
Locke, C., Zhang, H.X.
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