Results 111 to 120 of about 13,797,006 (300)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Cover -- Table of Contents -- 1 Introduction -- SOCIAL RIGHTS QUESTIONNAIRE FOR NATIONAL RAPPORTEURS INTERNATIONAL CONGRESS OF COMPARATIVE LAW 2014 VIENNA -- DROITS SOCIAUX: QUESTIONNAIRE POUR LES RAPPORTEURS NATIONAUX CONGRES INTERNATIONAL DE DROIT ...
Wojtyczek, Krzysztof.
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, 2013 Arabic version available in IDRC Digital LibraryThe Association for Women’s Rights in Development (AWID) hosted its 12th International Forum in Istanbul (2012), bringing together more than 2,200 women’s rights activists from around the world under the ...
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Beyond Civil Rights: Developing economic, social, and cultural rights in the uk [PDF]
, 2001 With the implementation of the Human Rights Act in 2000, the mainly civil and political rights set out in the European Convention on Human Rights are, for the first time, directly enforceable in UK law.
Karim, Razia, Ruxton, Sandy
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Social justice report 2012 [PDF]
, 2012 This report examines the enjoyment and exercise of human rights by Aboriginal and Torres Strait Islander peoples, and includes recommendations to help ensure their exercise and enjoyment of human rights.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source