Results 111 to 120 of about 3,546,996 (310)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Uzbekistan Supplementary NGO Report on the Implementation of the Convention on the Rights of the Child in the Republic of Uzbekistan [PDF]
, 2001 [Excerpt] The Convention on the Rights of the Child (CRC) was one of the first international instruments to which the Republic of Uzbekistan acceded, and with parliamentary ratification on 9 December 1992, the Republic of Uzbekistan entered into a ...
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
LA DIRECTIVA 2004/38/CE Y LA JURISPRUDENCIA DEL TJCE SOBRE EL DISFRUTE DE LAS PRESTACIONES SOCIALES: ¿FRENO AL AVANCE EN MATERIA SOCIAL O ADECUACIÓN A LOS INTERESES DE LOS ESTADOS? [PDF]
Revista d'Estudis Autonòmics i Federals, 2014 The aim of this contribution is to analyse the social model introduced by the Directive 2004/38/EC in the framework of the case-law of the European Court of Justice (ECJ). This contribution is divided in two sections.
Natalia Caicedo Camacho
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Nursing Students' Attitudes towards Immigrants' Social Rights. [PDF]
Int J Environ Res Public Health, 2020 Sánchez-Ojeda MA +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
OS INTELECTUAIS, A MILITÂNCIA NEGRA, A IGREJA E OS QUILOMBOLAS NA LUTA POR DIREITOS
Terra de Pretos, 2020 In this article, we discuss on the role of intellectuals, black militants and the Catholic Church in the struggle of the quilombola population in Maranhão for access to social rights.
Claudemir Sousa
doaj
Donning Coase‐coloured glasses: a property rights view of natural resource economics [PDF]
Economic analysis of natural resource and environmental issues inappropriately places too much emphasis on Pigouvian externalities and too little on Coasean property rights and transaction costs. The crucial questions are who has what property rights and
Anderson, Terry L.
core +1 more source