Results 111 to 120 of about 610,169 (309)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

LA DIRECTIVA 2004/38/CE Y LA JURISPRUDENCIA DEL TJCE SOBRE EL DISFRUTE DE LAS PRESTACIONES SOCIALES: ¿FRENO AL AVANCE EN MATERIA SOCIAL O ADECUACIÓN A LOS INTERESES DE LOS ESTADOS? [PDF]

open access: yesRevista d'Estudis Autonòmics i Federals, 2014
The aim of this contribution is to analyse the social model introduced by the Directive 2004/38/EC in the framework of the case-law of the European Court of Justice (ECJ). This contribution is divided in two sections.
Natalia Caicedo Camacho
doaj  

Nursing Students' Attitudes towards Immigrants' Social Rights. [PDF]

open access: yesInt J Environ Res Public Health, 2020
Sánchez-Ojeda MA   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Social Rights as Fundamental Rights XIXth International Congress of Comparative Law / Le XIXe Congres International de droit compare

open access: yes
Cover -- Table of Contents -- 1 Introduction -- SOCIAL RIGHTS QUESTIONNAIRE FOR NATIONAL RAPPORTEURS INTERNATIONAL CONGRESS OF COMPARATIVE LAW 2014 VIENNA -- DROITS SOCIAUX: QUESTIONNAIRE POUR LES RAPPORTEURS NATIONAUX CONGRES INTERNATIONAL DE DROIT ...
Wojtyczek, Krzysztof.
core  

SCIENCE IN THE SERVICE OF HUMAN RIGHTS

open access: yes, 2002
Introit -- Pt. I. International standards -- Ch. 1. Links between science and human rights -- Ch. 2. Science in the Universal Declaration of Human Rights -- Ch. 3.
Claude, Richard Pierre
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

OS INTELECTUAIS, A MILITÂNCIA NEGRA, A IGREJA E OS QUILOMBOLAS NA LUTA POR DIREITOS

open access: yesTerra de Pretos, 2020
In this article, we discuss on the role of intellectuals, black militants and the Catholic Church in the struggle of the quilombola population in Maranhão for access to social rights.
Claudemir Sousa
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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