Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The role of social role strain, psychological resources and perceiving diabetes as a priority with self-care in women with type 2 diabetes mellitus. [PDF]
BMC Womens HealthAzam UAA, Hashim SM, Hamzah Z, Ahmad N.
europepmc +1 more source
Normative Social Role Concepts in Early Childhood. [PDF]
Cogn Sci, 2019 Foster-Hanson E, Rhodes M.
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
(Re)Conceptualizing Sex and Gender in Physical Education through Social Role Theory. [PDF]
QuestMoss AC, Chen A.
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Short-term changes in social role statuses across young adulthood and their relation to heavy drinking in a given month. [PDF]
J Res AdolescFairlie AM +5 more
europepmc +1 more source
[Alcohol as cultural asset-a historical, anthropological, and therapeutic perspective on alcohol consumption and its social role in western societies]. [PDF]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2021 Heinz A, Daedelow LS.
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Perceptions of formal pharmacy leadership on the social role of the profession and its historical evolution: A qualitative study. [PDF]
Explor Res Clin Soc PharmAraújo-Neto FC +7 more
europepmc +1 more source