Results 91 to 100 of about 2,445,025 (302)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Plus largement, les sciences sociales…
Sociologies, 2012 The position presented in this paper can be summarized very simply: the future of sociology depends on the future of social sciences in general. This position implies a reflection on the specific features and contours of social sciences, in what forms ...
Michel Grossetti
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A General Case Study of Complexity Science: Analytical and Logical Interconnection Between Soft and Hard Sciences (Invited Paper) [PDF]
Journal of Systemics, Cybernetics and Informatics, 2018 Complexity science is gaining popularity due to its unique approach to address convoluted and multi-dimentional problems. In this work, we present a general case study of complexity science by means of analytical and logical interconnection between soft ...
Jack Jia-Sheng Huang, Yu-Heng Jan
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Objetividade e subjetividade nas ciências jurídicas e sociais: Durkheim e Weber
Revista da Faculdade de Direito da Universidade de Uberlândia, 2010 The birth of social sciences in the nineteenth century was marked by the reflection on the specific method that these sciences should conform, at the same time by the concern to give the autonomous meaning of causal relationships between social facts in ...
Cesar Antonio Serbena
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Survey of Theory-building Barriers in Social Sciences Area [PDF]
مدیریت بازرگانی, 2009 Social Sciences with such topics as human behavior, groups and communities, and in general deal with human and social systems. These subjects are very dynamic and variable, and form in complex interactions network.
Ali Asghar Pour Ezzat +2 more
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