Results 91 to 100 of about 4,094,474 (305)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A General Case Study of Complexity Science: Analytical and Logical Interconnection Between Soft and Hard Sciences (Invited Paper) [PDF]

Journal of Systemics, Cybernetics and Informatics, 2018
Complexity science is gaining popularity due to its unique approach to address convoluted and multi-dimentional problems. In this work, we present a general case study of complexity science by means of analytical and logical interconnection between soft ...
Jack Jia-Sheng Huang, Yu-Heng Jan
doaj  

Forecasting a Language Shift Based on Cellular Automata [PDF]

Language extinction as a consequence of language shifts is a widespread social phenomenon that affects several million people all over the world today.
Doris Ferreres, Francesc S. Beltran, Marc-Antoni Adell, Marcos Ruiz-Soler, Salvador Herrando, Violant Estreder   +5 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Social Life of Values [PDF]

The case of the Danish “cartoon war†was a premonition of things to come: accelerated social construction of inequalities and their accelerated symbolic communication, translation and negotiation.
Magala, S.J.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Classifications of Sociological Paradigms

Encyclopedia
In this entry paper, we propose a brief analysis of the use of the notion of “paradigm” in sciences in general and in social sciences and sociology in particular.
Alexandru-Cosmin Apostol, Romeo Asiminei
doaj   +1 more source

Mengakhiri Dikotomi Ilmu Dalam Dunia Pendidikan [PDF]

The separation of religion and general science has been proven to bear negative things for the future of people since by general knowledge only (both natural sciences and social sciences) has weaknesses.
Bisryi, H. (Hasan)
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Social Sciences and „The Nation’s Science”. Some considerations

Sfera Politicii, 2013
This article focuses on the contributions of the Monographic School members to social sciences in Romania of the interwar period. The main theories and methodologies configured and applied by these scientists are presented in broader, comparative ...
Alina Branda
doaj