Results 71 to 80 of about 2,445,025 (302)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Dimensions of Memory in Elderly Compared with Non-Elderly [PDF]

روانشناسی پیری, 2019
Growing old causes significant effects on cognitive and metacognitive processes and increases the likelihood of cognitive failure. The present study aimed to investigate various dimensions of memory in the elderly and compare it with non-elderly.
Kamran Yazdanbakhsh, Mohammad Jashenpour, Amir Sanjabi, Akram Abbariki   +3 more
doaj  

Modello sociale europeo, riformismo e scienze sociali

Quaderni di Sociologia, 2012
While the best moment of social sciences in Europe was the affirmation of the European social model (ESM), nowadays we are living in an age of marginalization of both social sciences and ESM. Social sciences have enhanced the growth of the ESM, and today
Francesco Sidoti
doaj   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Review of: "A Unified Psychology as Part of a General Social Science" [PDF]

, 2023
Dana Christensen
openalex   +3 more sources

Social Sciences Information Portal (SOSIG)

Cybrarians Journal, 2004
A case study on the famous social sciences information portal SOSIG discusses some of the portal’s characteristics. It begins with a general presentation of the portal, then discusses the portal as a model for an online academic library, the search ...
Mohamed Baqla
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

France:

Journal of Social Science Education, 2019
Purpose: After a short historical presentation, this country report highlights current developments of social science education in France and clarifies its general status in the French school system, giving not only information about the curricula ...
Christophe Straub, Claire Ravez
doaj   +1 more source