Results 81 to 90 of about 2,485,414 (304)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The new Scopus CiteScore formula and the Journal Impact Factor: a look at top ranking journals and middle ranking journals in the Scopus categories of General Physics and Astronomy, Materials Science, General Medicine and Social Sciences

Physical and Engineering Sciences in Medicine, 2020
J. Trapp
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

El concepto de "tradición" en la filosofía de las ciencias sociales y humanas

Nóesis, 2012
In order to be able to speak about what are social and human sciences in their epistemological discussion, it might be of use the analysis that some authors such as Kuhn, Laudan, Popper and Gadamer have said around the term "tradition" for the Philosophy
Renato Huarte Cuéllar
doaj  

Dimensions of Memory in Elderly Compared with Non-Elderly [PDF]

روانشناسی پیری, 2019
Growing old causes significant effects on cognitive and metacognitive processes and increases the likelihood of cognitive failure. The present study aimed to investigate various dimensions of memory in the elderly and compare it with non-elderly.
Kamran Yazdanbakhsh, Mohammad Jashenpour, Amir Sanjabi, Akram Abbariki   +3 more
doaj  

Generic Ethics Principles in Social Science Research [PDF]

, 2013
The written output of a series of three symposia held in the spring of 2013 on the topic of Generic Ethics Principles in Social Science Research. The format for each symposium was the same: a main speaker introduced a paper that had been circulated in advance and this was followed by two formal discussants and then participation from the floor ...
Lewis, Janet, Dingwall, Robert, Iphofen, Ron, Oates, John, Emmerich, Nathan   +4 more
openaire  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Relationship Between Sleep Quality with Cognitive Emotion Regulation Strategies and Brain-Behavioral Systems in Pregnant Women

مراقبت پرستاری و مامایی ابن سینا, 2018
Introduction: Reduction of the quality of sleep is one of the most common complaints of women during pregnancy that leads to negative consequences on the mental health of pregnant women.
Jahangir Karami, Khodamorad Momeni, Faride Alimoradi   +2 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Status Of Sociology As A Fundamental Social Science At Modern University

Društvene i Humanističke Studije, 2018
The modern university is a subject to notable changes during three previous decades. The Bologna concept of higher education is primarily focused on market principles and thus has caused stagnation in the field of social sciences and humanities, because ...
Biserka R. Košarac
doaj