Results 81 to 90 of about 2,445,025 (302)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Relationship Between Sleep Quality with Cognitive Emotion Regulation Strategies and Brain-Behavioral Systems in Pregnant Women

مراقبت پرستاری و مامایی ابن سینا, 2018
Introduction: Reduction of the quality of sleep is one of the most common complaints of women during pregnancy that leads to negative consequences on the mental health of pregnant women.
Jahangir Karami, Khodamorad Momeni, Faride Alimoradi   +2 more
doaj  

Classifications of Sociological Paradigms

Encyclopedia
In this entry paper, we propose a brief analysis of the use of the notion of “paradigm” in sciences in general and in social sciences and sociology in particular.
Alexandru-Cosmin Apostol, Romeo Asiminei
doaj   +1 more source

RECONCILING THE GENERAL AND THE UNIQUE AREA STUDIES, CASE STUDIES, AND HISTORY VERSUS THEORETICAL SOCIAL SCIENCE

Сравнительная политика, 2015
The article examines the problem of relations between the General and the Unique in the social and political sciences. The author highlights the different views on this perspective: some scientists explain specifi c cases by bringing them under general ...
F. Eidlin
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Social Sciences and „The Nation’s Science”. Some considerations

Sfera Politicii, 2013
This article focuses on the contributions of the Monographic School members to social sciences in Romania of the interwar period. The main theories and methodologies configured and applied by these scientists are presented in broader, comparative ...
Alina Branda
doaj