Results 91 to 100 of about 398,723 (286)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Socially-Aware Incentive Mechanism for Mobile Crowdsensing Service Market

, 2018
Mobile Crowdsensing has shown a great potential to address large-scale problems by allocating sensing tasks to pervasive Mobile Users (MUs). The MUs will participate in a Crowdsensing platform if they can receive satisfactory reward.
Luo, Jun, Nie, Jiangtian, Niyato, Dusit, Wang, Ping, Xiong, Zehui   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Flood Inundation Probability Estimation by Integrating Physical and Social Sensing Data: Case Study of 2021 Heavy Rainfall in Henan, China

Remote Sensing
Frequent flooding seriously affects people’s safety and economic construction, and assessing the inundation probability can help to strengthen the capacity of emergency management of floods.
Wenying Du, Qingyun Xia, Bingqing Cheng, Lei Xu, Zeqiang Chen, Xiang Zhang, Min Huang, Nengcheng Chen   +7 more
doaj   +1 more source

Sensor Networks: Physical and Social Sensing in the IoT. [PDF]

Sensors (Basel), 2023
De S, Moessner K.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dynamic Assessment of Population Exposure to Urban Flooding Considering Building Characteristics

Land
Under intensifying climate change impacts, accurate quantification of population exposure to urban flooding has become an imperative component of risk mitigation strategies, particularly when considering the dynamic nature of human mobility patterns ...
Shaonan Zhu, Xin Yang, Jiabao Yang, Jun Zhang, Qiang Dai, Zhenzhen Liu   +5 more
doaj   +1 more source

Environment [PDF]

Applications of remote sensing technology to wildlife preservation, pest control, strip mining, water quality monitoring, and wetlands mapping were discussed.
Myles, R. L.
core   +1 more source