Results 111 to 120 of about 27,929,644 (300)

The Impact of Debate Lessons, Powered by Generative AI, on Student Learning

IAFOR Journal of Education
Humanities education in Singapore at the secondary level emphasises the inquiry-based learning pedagogical approach to engage students, inculcate critical thinking skills, and achieve the necessary knowledge and skills outcomes stipulated by the national
Seow Yongzhi
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

İlköğretim 6. ve 7. Sınıf Sosyal Bilgiler Öğretim Programının Öğrenci Görüşlerine Göre Değerlendirilmesi Konya İli Örneği

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2009
Bu araştırmada 2005 sosyal bilgiler programının öğrenci görüşlerine göre değerlendirilmesi amaçlanmıştır. Araştırmanın evreni, Türkiye Cumhuriyeti Millî Eğitim Bakanlığı’na bağlıKonya ilindeki ilköğretim okullarında sosyal bilgiler dersini alan 6.
Hakan Akdağ
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Understanding agency and developing historical thinking through labour history in elementary school: A local history learning experience

Historical Encounters: A Journal of Historical Consciousness, Historical Cultures, and History Education, 2015
Local history has been much neglected in many social studies curricula, in spite of its potential for providing students with authentic and proximal objects of study for the development of historical thinking and understanding of historical agency.
Stéphanie Demers, David Lefrançois, Marc-André Ethier   +2 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Indices of Social Development

, 2011
Social development is about putting people at the centre of development. Since the 1990s there has been growing recognition that social development is critical for broader development outcomes, including sustainable economic growth.
Staveren, Prof. Dr. I. van (Erasmus University Rotterdam, International Institute of Social Studies) DAI=info:eu-repo/dai/nl/095049207, I. van Staveren   +1 more
core   +1 more source

The intersection of culture and behavior in social studies classrooms

, 2016
Social studies is a school subject that aims to enmesh local and global concerns and ways of understanding the world. This objective for teaching and learning presumes that students interact with social studies material from fixed and definable cultures,
Schlein, Candace, Taft, Raol, Ramsay, Crystal M.   +2 more
core   +1 more source