Results 91 to 100 of about 5,062,930 (310)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

A New Framework for Assessing the Benefits of Early Education [PDF]

open access: yes, 2004
This working paper is among a series of papers funded by the Pew Charitable Trusts through its "Advancing Quality Pre-K for All" initiative. The paper proposes that future preschool valuations devote appropriate attention to the related potential long ...

core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Health related quality of life and emergency department visits in adults of age ≥ 66 years: a prospective cohort study

open access: yesHealth and Quality of Life Outcomes, 2018
Background Age increases the risk of emergency department [ED] visits. Health related quality of life (HRQoL) is often estimated as an outcome of ED visits, but it can be a risk factor of ED visits. This study aims to assess the association of HRQoL with
Mahwish Naseer   +2 more
doaj   +1 more source

A case study of system change and the influence of change agents : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Education at Massey University [PDF]

open access: yes, 1974
The education system in Papua New Guinea over a three year period, underwent a massive re-organization that was unique in both its scope and the speed with which it was accomplished. The change from a highly centralized, fragmented system of education to
Christie, Donald Andrew
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Muatan Pendidikan Karakter pada Pembelajaran Ilmu Pengetahuan Sosial di Sekolah Dasar [PDF]

open access: yes, 2012
The character education content of Social Studies Education in Elementary School. One of the most important aspect in teaching Social Studies Education is to create holistic education contents.
Sudarmi, S. (Sri)
core  

Self-reported Experiences of Students with Autism Spectrum Disorder in Higher Education: A Population-based Sample [PDF]

open access: yes, 2020
Postsecondary education functions as the gateway to a host of positive adult outcomes, including financial independence, employment opportunities, and independent living.
Baczewski, Lauren Marie
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Environmental perceptions and social support as predictors of continued participation in nighttime physical activity

open access: yesBMC Public Health
Objective Guided by the Theory of Planned Behavior (TPB), this study investigates how perceived environment and social support are associated with the intention to sustain nighttime physical activity, with attitude tested as a mediating variable. Methods
Minghui Zhao   +4 more
doaj   +1 more source

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