Results 101 to 110 of about 28,097,799 (251)

Environmental perceptions and social support as predictors of continued participation in nighttime physical activity

BMC Public Health
Objective Guided by the Theory of Planned Behavior (TPB), this study investigates how perceived environment and social support are associated with the intention to sustain nighttime physical activity, with attitude tested as a mediating variable. Methods
Minghui Zhao, Jingtao Wu, Yanhong Shao, Jingying Chen, Li Ling   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Adolescent Mental Health from the Perspective of Ki Hadjar Dewantara

Jurnal Ilmiah Bimbingan Konseling Undiksha
The background of this research was based on the rising prevalence of mental disorders among adolescents, triggered by academic pressure, social dynamics, family environment, and the influence of the digital world.
Arya Djodipati, Poerwanti Hadi Pratiwi
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

INTEGRATING LOCAL COFFEE POTENTIAL INTO SOCIAL STUDIES USING COMMUNITY-BASED LEARNING TO ENHANCE STUDENTS’ CREATIVITY

Jurnal Pendidikan Ilmu Sosial
This study explores the integration of local coffee potential into Social Studies learning through a Community-Based Learning (CBL) approach to enhance students’ creativity in junior high schools located in coffee-producing areas of Jember Regency ...
Amri Dhimas Maulana, Aim Abdulkarim, Enok Maryani, Erlina Wiyanarti, Sona Minasyan, Ahmad Syariful Jamil   +5 more
doaj  

Marital control, domestic violence justification, and mental health: a study of married women in Bangladesh

BMC Psychiatry
Marital control and culturally accepted justifications of domestic violence are pervasive forms of gendered power imbalances that undermine women’s autonomy and significantly contribute to adverse mental health outcomes.
Mortuja Mahamud Tohan, Sayeeda Zaman, Bristi Rani Saha, Nushrath Jahan Juhi, Shaiya Binte Mahbub, Md. Hasan Howlader   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Dark personality traits and deception, and the short dark tetrad (SD4) as integrity screening instrument

Scientific Reports
Dark personality traits (Machiavellianism, Narcissism, Psychopathy, and Sadism) have been associated with aversive, unethical, and criminal conduct. Concise measurement tools such as the Short Dark Tetrad (SD4) are popular, because they lend themselves ...
Eric Rassin, Melissa de Roos, Josanne van Dongen   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source