Results 101 to 110 of about 5,062,930 (310)

Pedagogy - a holistic, personal approach to work with children and young people, across services: European models for practice, training, education and qualification [PDF]

, 2009
Today, provision for children and young people is developing rapidly at the level of policy, organisation, training, education, and qualifications. Research in these areas, carried out at the Thomas Coram Research Unit (TCRU), has included cross-national
Boddy, Janet, Cameron, Claire, Heptinstall, Ellen, McQuail, Susan, Petrie, Pat, Simon, Antonia, Wigfall, Valerie   +6 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Marital control, domestic violence justification, and mental health: a study of married women in Bangladesh

BMC Psychiatry
Marital control and culturally accepted justifications of domestic violence are pervasive forms of gendered power imbalances that undermine women’s autonomy and significantly contribute to adverse mental health outcomes.
Mortuja Mahamud Tohan, Sayeeda Zaman, Bristi Rani Saha, Nushrath Jahan Juhi, Shaiya Binte Mahbub, Md. Hasan Howlader   +5 more
doaj   +1 more source

The Effect of Digital Learning Media Utilization and Learning Motivation on Learning Participation

Jurnal Inovasi Pendidikan dan Sains
This study aims to analyze the effects of digital learning media and learning motivation on students’ learning participation in the Science and Social Science (IPAS) subject at the elementary school level.
Siti Asrofah, Sulastri Rini Rindrayani, Kadeni Kadeni   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Dark personality traits and deception, and the short dark tetrad (SD4) as integrity screening instrument

Scientific Reports
Dark personality traits (Machiavellianism, Narcissism, Psychopathy, and Sadism) have been associated with aversive, unethical, and criminal conduct. Concise measurement tools such as the Short Dark Tetrad (SD4) are popular, because they lend themselves ...
Eric Rassin, Melissa de Roos, Josanne van Dongen   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Service Difficulties, Internal Resolution Mechanisms, and the Needs of Social Services in Hungary—The Baseline of a Development Problem Map

Social Sciences
This study focuses on the current service/care difficulties and challenges that social institutions in Hungary are facing during their daily operations; how they can react to them utilizing their internal resources, mechanisms, and capacities; and what ...
Zoltán Csizmadia, Krisztina Kóbor, Péter Tóth, Tamara Zsuzsanna Böcz   +3 more
doaj   +1 more source

"Stratification and Mortality - A Comparison of Education, Class, Status and Income" [PDF]

In many analyses of social inequality in health, different dimensions of social stratification have been used more or less interchangeably as measures of the individual’s general social standing.
Erikson, Robert, Torssander, Jenny
core