Results 81 to 90 of about 6,281,021 (307)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Environmental perceptions and social support as predictors of continued participation in nighttime physical activity

BMC Public Health
Objective Guided by the Theory of Planned Behavior (TPB), this study investigates how perceived environment and social support are associated with the intention to sustain nighttime physical activity, with attitude tested as a mediating variable. Methods
Minghui Zhao, Jingtao Wu, Yanhong Shao, Jingying Chen, Li Ling   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Marital control, domestic violence justification, and mental health: a study of married women in Bangladesh

BMC Psychiatry
Marital control and culturally accepted justifications of domestic violence are pervasive forms of gendered power imbalances that undermine women’s autonomy and significantly contribute to adverse mental health outcomes.
Mortuja Mahamud Tohan, Sayeeda Zaman, Bristi Rani Saha, Nushrath Jahan Juhi, Shaiya Binte Mahbub, Md. Hasan Howlader   +5 more
doaj   +1 more source

The Effect of Digital Learning Media Utilization and Learning Motivation on Learning Participation

Jurnal Inovasi Pendidikan dan Sains
This study aims to analyze the effects of digital learning media and learning motivation on students’ learning participation in the Science and Social Science (IPAS) subject at the elementary school level.
Siti Asrofah, Sulastri Rini Rindrayani, Kadeni Kadeni   +2 more
doaj   +1 more source

A study on the efficacy of project-based learning approach on Social Studies Education: Conceptual achievement and academic motivation

, 2014
In this research, an experimental study was carried out in social studies 4th grade students’ to develop students’ conceptual achievement and motivation to succeed academically.
Ilhan Ilter
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dark personality traits and deception, and the short dark tetrad (SD4) as integrity screening instrument

Scientific Reports
Dark personality traits (Machiavellianism, Narcissism, Psychopathy, and Sadism) have been associated with aversive, unethical, and criminal conduct. Concise measurement tools such as the Short Dark Tetrad (SD4) are popular, because they lend themselves ...
Eric Rassin, Melissa de Roos, Josanne van Dongen   +2 more
doaj   +1 more source