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Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek+15 more
wiley +1 more source
Semantic Web Approach towards Interoperability and Privacy issues in Social Networks [PDF]
The Social Web is a set of social relations that link people through World Wide Web. This Social Web encompasses how the websites and software are designed and developed to support social relations. The new paradigms, tools and web services introduced by Social Web are widely accepted by internet users.
arxiv +1 more source
Perceived Social Support among Chinese American Hemodialysis Patients [PDF]
Social support is linked to improved health outcomes both in Western and Asian societies and is a vital factor in a patient\u27s adjustment to end-stage renal disease and its treatment regimen.
Wong, Kaklam
core +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
A stepwise emergence of evolution in the RNA world
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Social support and social structure [PDF]
The burgeoning study of social support in relation to social stress and health would benefit from increased attention to issues of social structure. Three aspects of social relationships, all often referred to as social support, must be more clearly distinguished—(1) their existence or quantity (i.e., social integration), (2) their formal structure (i ...
openaire +3 more sources
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp+5 more
wiley +1 more source
The Social Protection Support Project in the Philippines [PDF]
Key Points The Pantawid Pamilya conditional cash transfer program reached more than 4.4 million poor families in 2014. Rigorous impact evaluation in 2012 and 2014 confirms that Pantawid Pamilya improves access to health services, keeps children in ...
Schelzig, Karin
core +1 more source
Social support for South Asian Muslim parents with life-limiting illness living in Scotland:a multiperspective qualitative study [PDF]
Objective: To explore experiences of social support needs among South Asian Muslim patients with life-limiting illness, living in Scotland, who are parents of young children.
Gaveras, Eleni Margareta+4 more
core +2 more sources
Educating Students with Autism Spectrum Disorders: Organizational Problems
The article presents data of applied socio-psychological research devoted to the study of difficulties encountered by educational institutions when teaching children with autism spectrum disorders (ASD).
Samsonova E.,, Alekseeva M.N.,
doaj +1 more source