Results 141 to 150 of about 1,512,127 (308)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Assessing the role of citizen science in the validation of remote sensing habitat classifications

Ecological Solutions and Evidence
Habitat degradation requires increased environmental monitoring to enable conservation activities. Citizen Science (CS) and Remote Sensing (RS) are scalable approaches to broaden biodiversity monitoring.
Samantha Suter, Brian Barrett, Natalie Welden   +2 more
doaj   +1 more source

A call to action: Unpacking the challenges to implementing social sustainability initiatives in a developing country city. [PDF]

Heliyon, 2023
Razia S, Abu Bakar Ah SH.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Editorial: Social sustainability at work: A key to sustainable development in business. [PDF]

Front Psychol, 2022
Rank S, Contreras F, Abid G.
europepmc   +1 more source

Informational precaution [PDF]

, 2010
In environmental ethics, the precautionary principle states that parties should refrain from actions in the face of scientific uncertainties about serious or irreversible harm to public health or the environment.
Pieters, Wolter
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

New Conceptual Model of Social Sustainability: Review from Past Concepts and Ideas. [PDF]

Int J Environ Res Public Health, 2023
Ly AM, Cope MR.
europepmc   +1 more source

Sustainable management: a strategic challenge for a global minerals and metals industry

, 2010
This paper refers to the concept of sustainable management as the management approach which efficiently integrates economic, environmental and social issues into the operations of the minerals and metals industries, with the aim of creating long-term ...
Botin Gonzalez, Jose Antonio, Palacios, Miguel de   +1 more
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source