Results 81 to 90 of about 12,087,707 (288)

Semantic Editions of Classical Texts: How Social Networks Change Cognitive Strategies of Interaction with Literary Heritage

open access: yesВиртуальная коммуникация и социальные сети, 2023
The paper introduces the phenomenon of semantic editions: a new digital representation of texts and personalities of the Great Literature, e. g., The World of Dante, Mapping the Republic of Letters, Chekhov Digital, Tolstoy Digital, and Pushkin Digital ...
Anastasia V. Kolmogorova
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Social tagging and library catalog [PDF]

open access: yes, 2019
Rad se bavi ulogom društvenog označivanja (social tagging) u pretraživanju web kataloga i razlikama takvoga načina klasifikacije u odnosu na uobičajene kontrolirane rječnike koje koristi većina knjižnica.
Vukšić, Stipe
core   +1 more source

Status, identity, and language: A study of issue discussions in GitHub.

open access: yesPLoS ONE, 2019
Successful open source software (OSS) projects comprise freely observable, task-oriented social networks with hundreds or thousands of participants and large amounts of (textual and technical) discussion. The sheer volume of interactions and participants
Jingxian Liao   +4 more
doaj   +1 more source

Una experiencia de aprendizaje con etiquetado social || A learning experience based on social tagging

open access: yesRevista de Estudios e Investigación en Psicología y Educación, 2015
Se exponen aquí los resultados de una experiencia educativa mediada con TIC donde jugó un papel relevante el empleo del etiquetado social o conjuntos de etiquetas creadas por múltiples usuarios en espacios web 2.0.
Francisco José Santos-Caamaño   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Ensuring the discoverability of digital images for social work education : an online tagging survey to test controlled vocabularies [PDF]

open access: yes, 2009
The digital age has transformed access to all kinds of educational content not only in text-based format but also digital images and other media. As learning technologists and librarians begin to organise these new media into digital collections for ...
Daly, Ellen Katherine, Ballantyne, Neil
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Elements of social representation theory incollaborative tagging systems

open access: yesTransinformação, 2014
This article discusses the information representation process based on the Moscovici's Social Representation Theory and domain analysis in Information Science.
Patricia Zeni Marchiori   +4 more
doaj  

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