Results 151 to 160 of about 1,363,241 (318)
Ideal and nonideal theory: A conceptual overview
, 2013 The article gives conceptual clarification on a distinction between ideal and nonideal theory by analyzing John Rawls´ theory as presented in his books “A Theory of Justice” and ”The Law of Peoples.“ The article tries to show the importance of ideal ...
Milica Trifunovic +2 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Human rights and critical social work: competing epistemologies for practice
, 2016 The paper argues that the idea of human rights remains a 'two-edged sword' for critical social work practice. On one hand, human rights implies a progressive stance for critical social workers.
Ife, Jim +4 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Social Balance Theory: Revisiting Heider’s Balance Theory for many agents [PDF]
We construct a model based on Heider’s social balance theory to analyze the interpersonal network among social agents. The model of social balance theory provides us an interesting tool to see how a social group evolves to the possible balance state.
Deni Khanafiah, Hokky Situngkir
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Intersubjectivity of Affect and Social Change
The main goal of the panel is to discuss a theoretical insight into the processes through which political affects could become intersubjective and create a potential for social change, particularly in the context of major societal crises such as the 2008
Nikolić, Olga +4 more
core