Results 141 to 150 of about 16,758,560 (308)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Social Cognition and Theory of Mind
For an individual to exist in a society, they must be receptive to not only signals from their natural environment but also to those from their social environment.
Atacan Yaşgüçlükal, MİRAY +5 more
core +1 more source
Collapsed publics: Orality, literacy, and vulnerability in academic Twitter [PDF]
, 2016 This paper outlines ways in which scholars build identity and connection on open networked platforms such as Twitter, and considers the risks and benefits of networked participatory engagement.
Stewart, Bonnie
core
The Emergence of Social Theory
, 2021 The emergence of “social theory” as a distinct intellectual genre represents a historic renewal of considerable importance. Tracing the development of key concepts allows us to understand its analytical specificity as compared to the traditional genres ...
Heilbron, Johan
core
The depoliticization of protest: understanding the 2024/2025 Serbian students’ uprising
Cogent Social SciencesThe 2024/2025 student protests in Serbia emerged in the wake of a deadly infrastructural collapse in Novi Sad, catalyzing nationwide outrage and revealing systemic failures rooted in corruption and political cronyism.
Aleksandra Jerkov +2 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Intersubjectivity of Affect and Social Change
The main goal of the panel is to discuss a theoretical insight into the processes through which political affects could become intersubjective and create a potential for social change, particularly in the context of major societal crises such as the 2008
Nikolić, Olga +4 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source