Results 131 to 140 of about 17,284,781 (307)

Theory on the other Side of the Veil: Reckoning with Legacies of Anti-Blackness and Teaching in Social Theory. [PDF]

Am Sociol, 2021
Fillingim A, Rucks-Ahidiana Z.
europepmc   +1 more source

Social Theory And The Analysis Of Transactions

Soft Power, 2016
Este articulo analiza una seria objecion a las teorias sociales que apoyan los mecanismos apagados y las fuerzas escondidas que, a su vez, influyen en los actores sociales: ellas destacan la necesidad teorica de confirmar sus presuposiciones tanto si ellas son demostradas como si son desmentidas por los fenomenos en los que ellas mismas se centran.
openaire   +4 more sources

The Emergence of Social Theory

, 2021
The emergence of “social theory” as a distinct intellectual genre represents a historic renewal of considerable importance. Tracing the development of key concepts allows us to understand its analytical specificity as compared to the traditional genres ...
Heilbron, Johan
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Educational Journeys Through Time: Overview and Impacts

Etnoantropološki Problemi
This paper examines the profound impact of travel on educational experiences considering contemporary and historical journeys. It highlights the intricate relationship between education and experience, emphasizing their continued relevance in the context
Sanja Iguman Glušac, Predrag Krstić, Aleksandar Ostojić   +2 more
doaj   +1 more source

Towards an Emotionally Conscious Social Theory [PDF]

This article attempts to contribute to the on-going discussion regarding the 'future of sociology and social theory' by suggesting that classical and contemporary social theories have yet to provide satisfactory accounts of the emotional components of ...
Benet Davetian
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Using theoretical frameworks from the social sciences to understand and explain behaviour in social computing

, 2011
Research over the past 15 years has examined how the Internet is being used to support communication and social interaction across a variety of groups and communities. However, much of this research has been exploratory, rather than explanatory.
Taylor-Jackson, Jacqui (R19920)
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source