Results 131 to 140 of about 16,758,560 (308)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An Aesthetic Education of Social Theory : Some Comments on Robin Wagner-Pacifici’s What is an Event?
, 2018 An essay on Robin Wagner-Pacifici's 'What Is and Event?' (2017). The essay argues that Wagner-Pacifici's book offers a platform from which it again becomes possible to rethink the relationship between system and transformation, and that this is precisely
Jonsson, Stefan +2 more
core +1 more source
InformaticsAs artificial intelligence (AI) becomes ubiquitous across various fields, understanding people’s acceptance and trust in AI systems becomes essential.
Letizia Aquilino +5 more
doaj +1 more source
CART-analysis embedded in social theory: A case study comparing quantitative data analysis strategies for intersectionality-based public health monitoring within and beyond the binaries. [PDF]
SSM Popul Health, 2021 Mena E +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Theory of the Social, Theory as the Social : On the Self-Application of Sociological Theory
Theory of the Social, Theory as the Social : On the Self-Application of Sociological TheoryThe purpose of this article is to show that scientific theory is a social system consisting of communication. Applying this to sociological theory, we realize that it is not just a theory of the social, but it is itself the social. Talcott Parsons, referring to Edmund Husserl’s Logical Investigations, regarded scientific theory as a transcendent Idea ...
openaire +1 more source
, 2003 This chapter examines the role of nonsocial reinforcement as stated in Ronald L. Akers' social learning theory of crime and deviance. It also examines the ability of the theory–as formulated–to account for individual differences in the propensity to ...
Brezina, Timothy, Piquero, Alex R
core +1 more source