Results 121 to 130 of about 28,121,044 (303)
臺灣教育社會學研究, 2010 本文旨在建立「科舉文明」這一理念型概念，以做為解釋反對教改諸種議題相關的社會結構基礎。透過科舉制度的傳統，教育與社會地位／階級／關係／家庭主義的教條之關係被緊密相連起來。雖然臺灣社會正在變遷當中，但是教改所威脅到的科舉考試傳統仍被視為是反抗教改之社會解釋的基礎。本研究發現，升學主義並不是迷信，而是科舉文明豐富內涵之中的一項行動機制，而升學考試制度則是國家與人民在政治經濟學上精算的結果。 In this article the grounds for a social explanation of ...
林民程 Min-Cheng Lin
doaj
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Journal of Benefit-Cost Analysis, 2013 Mark A. Moore, A. Boardman, A. Vining
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Social time pressure, sleep, and eating rhythms-lessons from a pandemic "natural experiment". [PDF]
SleepArab A, Scheer FAJL.
europepmc +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Relaxation of social time pressure reveals tight coupling between daily sleep and eating behavior and extends the interval between last and first meal. [PDF]
SleepKorman M +8 more
europepmc +1 more source