Results 141 to 150 of about 9,605,060 (300)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Systematic literature review of the relationship between adolescents' screen time, sleep and mental health [PDF]

, 2020
Martin, Anne, McDaid, Lisa, McMellon, Christina, Pugmire, Juliana, Riddell, Julie, Simpson, Sharon, Skivington, Kathryn, Wells, Valerie   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modelando tiempo y espacio

Revista de Ciencias Economicas, 2008
En este artículo se elaboran modelos de las ideas de tiempo y espacio social de Anthony Giddens o, por lo menos, compatibles con ellas. Hacia tal efecto, se aplican instrumentos gráficos y matemáticos para combinar conceptos cualitativos y cuantitativos,
Róger Churnside Harrison
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Social violence: Time to Innovate [PDF]

Surgical Innovation, 2017
Lee L, Swanström, Adrian, Park
openaire   +2 more sources

Quakers and Creation Care: Potentials and Pitfalls for an Ecotheology of Friends (Chapter Five in Quakers, Creation Care, and Sustainability)

, 2019
While Friends have a strong tradition of activism around the social justice issues of each era, we also tend to spiritualize our faith, disconnecting it from the material world. Environmental concerns are arguably one of the most important social justice
Bock, Cherice
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

科舉文明：被視為臺灣教育改革阻力的文化 Civil Service Examination Civilization: The Culture of the Resistance to the Taiwan Educational Reforms

臺灣教育社會學研究, 2010
本文旨在建立「科舉文明」這一理念型概念，以做為解釋反對教改諸種議題相關的社會結構基礎。透過科舉制度的傳統，教育與社會地位／階級／關係／家庭主義的教條之關係被緊密相連起來。雖然臺灣社會正在變遷當中，但是教改所威脅到的科舉考試傳統仍被視為是反抗教改之社會解釋的基礎。本研究發現，升學主義並不是迷信，而是科舉文明豐富內涵之中的一項行動機制，而升學考試制度則是國家與人民在政治經濟學上精算的結果。 In this article the grounds for a social explanation of ...
林民程 Min-Cheng Lin
doaj