Results 121 to 130 of about 26,978,530 (253)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Modelando tiempo y espacio

open access: yesRevista de Ciencias Economicas, 2008
En este artículo se elaboran modelos de las ideas de tiempo y espacio social de Anthony Giddens o, por lo menos, compatibles con ellas. Hacia tal efecto, se aplican instrumentos gráficos y matemáticos para combinar conceptos cualitativos y cuantitativos,
Róger Churnside Harrison
doaj  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

科舉文明:被視為臺灣教育改革阻力的文化 Civil Service Examination Civilization: The Culture of the Resistance to the Taiwan Educational Reforms

open access: yes臺灣教育社會學研究, 2010
本文旨在建立「科舉文明」這一理念型概念,以做為解釋反對教改諸種議題相關的社會結構基礎。透過科舉制度的傳統,教育與社會地位/階級/關係/家庭主義的教條之關係被緊密相連起來。雖然臺灣社會正在變遷當中,但是教改所威脅到的科舉考試傳統仍被視為是反抗教改之社會解釋的基礎。本研究發現,升學主義並不是迷信,而是科舉文明豐富內涵之中的一項行動機制,而升學考試制度則是國家與人民在政治經濟學上精算的結果。 In this article the grounds for a social explanation of ...
林民程 Min-Cheng Lin
doaj  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Art, Time and Consciousness

open access: yes, 2006
Philosophical conceptions of time seem to fall into two groups, “flow” (river, arrow) and “block”: both of them spatialised. Kant was an important exception, and modern subjectivist thinking about time, or about the consciousness of time, seems to have ...
Haines, Simon
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

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