Results 81 to 90 of about 527,075 (305)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Assessing trust through social capital? A possible experimental answer. [PDF]
Trust is an important variable in economics, as several transactions are based on it; unfortunately it is difficult to measure. The recent economic literature on social capital shows a positive association between this concept and trust.
Migheli, Matteo
core
Does Social Capital Create Trust? Evidence from a Community of Entrepreneurs [PDF]
Which kind of social capital fosters the diffusion of development-oriented trust? This paper carries out an empirical investigation into the causal relationships connecting four types of social capital (i.e.
Fabio Sabatini
core +2 more sources
The management of COVID-19 in prisons – the case of Northern Ireland
Health & JusticeBackground This paper describes COVID-19 cases in the Northern Ireland (NI) prison population during the pandemic in relation to the general population and changes implemented to control infection in NI prisons.
Dermot O’Reilly +9 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Who trusts? The origins of social trust in seven nations [PDF]
This paper identifies six main theories of the determinants of social trust, and tests them against survey data from seven nations, 1999-2001. Three of the six theories of trust fare rather poorly and three do better.
Newton, Kenneth, Delhey, Jan
core
Health Technology AssessmentBackground In patients who require mechanical ventilation for acute hypoxaemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.
James J McNamee +6 more
doaj +1 more source
European PsychiatryIntroduction Antipsychotic medications are essential for managing psychiatric disorders, offering symptom relief and improved functioning. However, their use carries potential risks.
M. Elesawy, G. J. Munday, N. Lekka
doaj +1 more source
Pediatric intraorbital abscess: Early recognition and management
Clinical Case Reports, 2019 Key Clinical Message Orbital involvement occurs in 85% of complicated acute sinusitis and is more prevalent in children. Prompt differentiation between the more common periorbital (preseptal) cellulitis and infections, posterior to the orbital septum ...
Dominic McKenna +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source