Results 101 to 110 of about 2,631,562 (303)

Developing the New Kent Complex Psychosis Service (KCPS): Reducing the Limitations Imposed by Treatment-Resistant Psychosis

BJPsych Open
Aims A third to a half of patients with psychosis fail to recover to premorbid levels of functioning. Within these are a group of patients with treatment-resistant psychotic disorders, whose presentations are complex, with significant comorbidities ...
Aderopo Adelola, Eromona Whiskey, Patricia Morgan, Agostina Secchi, Hayley Stentzel   +4 more
doaj   +1 more source

How motivations of SNSs use and offline social trust affect college students' self-disclosure on SNSs: An investigation in China [PDF]

Social Networking Sites (SNSs) have been proliferating and growing in popularity worldwide throughout the past few years, which have received significant interest from researchers.
Peiyi, Huang, Weiwei, Zhang
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Population-based screening for Lynch syndrome in patients with colorectal cancer: implementing the NICE diagnostic pathway

BMJ Connections. Clinical Genetics and Genomics
Background Lynch syndrome (LS) is defined by having a pathogenic constitutional variant affecting one of the four mismatch repair (MMR) genes: MSH2, MLH1, MSH6 or PMS2.
Paul Kelly, Manuel Salto-Tellez, Tabib Dabir, Jacqueline James, Sean Hegarty, Peter Logan, Claire Byrne, Gillian Rea, Christine Quinn, Sianan MacParland, Mark Catherwood, Clare Crean, Lauren McConnell, Beatriz Cutillas-Moreno, Anthony Abladey, Olivia Sharpe, Maurice Loughry   +16 more
doaj   +1 more source

The Use and Abuse of Trust: Social Capital and its Deployment by Early Modern Guilds [PDF]

Guilds are social scientists’ favoured historical example of institutions generating a ‘social capital’ of trust that benefited entire economies. This article considers this view in the light of empirical findings for early modern Europe.
Sheilagh Ogilvie
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The courage to venture: Revealing the effect of social trust on corporate venture capital. [PDF]

PLoS One, 2023
Zhang Y, Guo X.
europepmc   +1 more source

Growth aspirations and social capital: Young firms in a post-conflict environnment [PDF]

, 2013
We explore the social determinants of growth aspirations of young firms’ owners and managers in a post-conflict economy. We focus on social capital, which we treat as a multi-dimensional phenomenon, studying not only the effect of owners’ and managers ...
Efendic, A, Mickiewicz, T, Rebmann, A
core  

Astuteness, Trust, and Social Intelligence

Journal for the Theory of Social Behaviour, 2006
The strategic thinking people use to achieve personal gains has been studied in psychology as Machivellianism, however, Machiavellianism is a problematic construct due to the negative moral implications and its association with psychopathology. The article introduces the concept of astuteness as an alternative notion to study the everyday tactical ...
openaire   +1 more source