Results 111 to 120 of about 2,631,562 (303)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A novel linked dataset to improve understanding about the health of people in Northern Ireland’s prisons

International Journal of Population Data Science
Objective and Approach We describe a collaboration between the Queen’s University Belfast, Administrative Data Research Centre (ADRC) in Northern Ireland (NI) and the NI Healthcare in Prisons Service (HIPS) to develop a novel linked database to assess ...
Janine Cooper, Dermot O’Reilly, Trish Kelly, Richard Kirk, Stephen McGarrigle, Ruth Gray, Michael Donnelly   +6 more
doaj   +1 more source

Interdependence Between Social Values and National Performance Indicators: The Case of the Enlarged European Union [PDF]

Based on the desk research, the paper provides an empirical insight into correlations between some social values and five selected economic performance indicators for 20 European Union countries. We concentrated on Composite Trust.
Cene Bavec
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Developing and Integrating Regular Training in Serious Incident Investigations and Coroner’s Inquests Into the Higher Trainees Teaching at Kent and Medway NHS and Social Care Partnership Trust (KMPT)

BJPsych Open
Aims: This project aims to develop and integrate regular training on Serious Incident (SI) Investigations and Coroner’s Inquests into the Higher Trainees Teaching at Kent and Medway NHS and Social Care Partnership Trust (KMPT).
Maria Moisan, Chiara Rubino, Rachel Daly
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Re-Audit of Adherence to Antipsychotic Prescribing Guidelines in a Psychiatric Unit for Older Adult Females: Evaluating Improvements and Compliance Post-Interventions

BJPsych Open
Aims: The aim of this audit was to assess adherence to antipsychotic prescribing guidelines in one of the Older Adults Female wards at Kent and Medway NHS and Social Care Partnership Trust (KMPT).
Maria Moisan, Daisy Carroll, Ayebatonye Ajiteru   +2 more
doaj   +1 more source

Trusting only whom you know, knowing only whom you trust: the joint impact of social capital and trust on individuals’ economic performance and happiness in CEE countries [PDF]

This paper demonstrates that bridging and bonding social capital as well as social trust interdependently affect individuals’ earnings and happiness.
Jakub Growiec, Katarzyna Growiec
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Challenges and Delay in Treatment With Clozapine Due to Thrombocytopenia: A Case Study

BJPsych Open
Aims Clozapine is the most effective antipsychotic medication for patients with treatment-resistant psychotic disorders. Its discontinuation can precipitate relapse that can be often challenging to treat.
Suresh Thapaliya, Glenda Boutell, Mudasir Firdosi   +2 more
doaj   +1 more source