Results 91 to 100 of about 12,821,290 (253)

SOCIAL CAPITAL, TRUST, AND THE AGRIBUSINESS OF ECONOMICS [PDF]

Economists, including agricultural economists, have a long history of recognizing the importance of the behavioral foundations in decision making while ignoring these observable human dimensions in their economic models.
Wilson, Paul N.
core  

Population-based screening for Lynch syndrome in patients with colorectal cancer: implementing the NICE diagnostic pathway

BMJ Connections Clinical Genetics and Genomics
Background Lynch syndrome (LS) is defined by having a pathogenic constitutional variant affecting one of the four mismatch repair (MMR) genes: MSH2, MLH1, MSH6 or PMS2.
Paul Kelly, Manuel Salto-Tellez, Tabib Dabir, Jacqueline James, Sean Hegarty, Peter Logan, Claire Byrne, Gillian Rea, Christine Quinn, Sianan MacParland, Mark Catherwood, Clare Crean, Lauren McConnell, Beatriz Cutillas-Moreno, Anthony Abladey, Olivia Sharpe, Maurice Loughry   +16 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

College Education and social trust. An Evidence-based Study on the Causal Mechanisms [PDF]

This paper examines the influence of college education on social trust at the individual level. Based on the literature of trust and social trust, we hypothesize that life experience/development since adulthood and perceptions of cultural/social ...
Groot, W., Maassen van den Brink, H., Huang, J.   +2 more
core  

A novel linked dataset to improve understanding about the health of people in Northern Ireland’s prisons

International Journal of Population Data Science
Objective and Approach We describe a collaboration between the Queen’s University Belfast, Administrative Data Research Centre (ADRC) in Northern Ireland (NI) and the NI Healthcare in Prisons Service (HIPS) to develop a novel linked database to assess ...
Janine Cooper, Dermot O’Reilly, Trish Kelly, Richard Kirk, Stephen McGarrigle, Ruth Gray, Michael Donnelly   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developing and Integrating Regular Training in Serious Incident Investigations and Coroner’s Inquests Into the Higher Trainees Teaching at Kent and Medway NHS and Social Care Partnership Trust (KMPT)

BJPsych Open
Aims: This project aims to develop and integrate regular training on Serious Incident (SI) Investigations and Coroner’s Inquests into the Higher Trainees Teaching at Kent and Medway NHS and Social Care Partnership Trust (KMPT).
Maria Moisan, Chiara Rubino, Rachel Daly
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Re-Audit of Adherence to Antipsychotic Prescribing Guidelines in a Psychiatric Unit for Older Adult Females: Evaluating Improvements and Compliance Post-Interventions

BJPsych Open
Aims: The aim of this audit was to assess adherence to antipsychotic prescribing guidelines in one of the Older Adults Female wards at Kent and Medway NHS and Social Care Partnership Trust (KMPT).
Maria Moisan, Daisy Carroll, Ayebatonye Ajiteru   +2 more
doaj   +1 more source