Results 161 to 170 of about 19,273,452 (314)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Community Engagement in Research: An Antidote to the Social Value Misconception. [PDF]

Am J Bioeth
Chessa F.
europepmc   +1 more source

Social value of pathology: adapting primary health care to reduce stress and social anxiety in college students exposed to social distancing. [PDF]

Front Psychol, 2023
Sava IN.
europepmc   +1 more source

Social value creation as a core determinant from the impact of social entrepreneurship

Loris O. Gillin
openalex   +1 more source

Are values in the Benelux countries comparable? Testing for equivalence with the European Social Survey

, 2007
Eldad Davidov, Peter Schmidt
openalex   +1 more source

Oxytocin modulates social value representations in the amygdala

Nature Neuroscience, 2019
Yunzhe Liu, Shiyi Li, Wanjun Lin, Wenxin Li, Xinyuan Yan, Xuena Wang, Xinyue Pan, R. Rutledge, Yina Ma   +8 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Reimagining Social Value to Consider the Environment: How Should We Judge the Magnitude of Benefits in Health Research? [PDF]

Bioethics
Pratt B, van der Graaf R.
europepmc   +1 more source

Social Value Orientation Moderated the Effect of Acute Stress on Individuals' Prosocial Behaviors. [PDF]

Front Psychol, 2022
Ying L, Yan Q, Shen X, Zhang C.
europepmc   +1 more source