Results 51 to 60 of about 188,750 (294)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Desenvolvimento e Meio Ambiente, 2016 The notion of vulnerability has been used in various fields of knowledge. One of its uses is in interdisciplinary research on environmental vulnerability, in which is understood in a simplified way as the overlap of social vulnerability and environmental
Natália Tavares Azevedo
doaj +1 more source
Assessment of social vulnerability to natural hazards in Nepal [PDF]
Natural Hazards and Earth System Sciences, 2017 This paper investigates district-wide social vulnerability to natural hazards in Nepal. Disasters such as earthquakes, floods, landslides, epidemics, and droughts are common in Nepal.
D. Gautam
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Scientific ReportsInvestigating social vulnerability is a crucial aspect of attaining an in-depth understanding of disasters and disaster risk. This study developed a measurement framework for social vulnerability to geological disasters, obtained a comprehensive social ...
Yan Jia, Shuo Jia, Ruiqiu Pang
doaj +1 more source
Study of Integrated Social Vulnerability Index SoVIint of Hilly Region of Uttarakhand, India
Environmental and Climate Technologies, 2020 The hilly regions of India have suffered many disasters, both natural and anthropogenic. In the hilly state like Uttarakhand, the hazards like flash flood, forest fires, and landslide affect the community at the large scale.
Kumar Dilip, Kumar Bhattacharjya Rajib
doaj +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Social and healthcare reforms and vulnerable groups [PDF]
Nordic Studies on Alcohol and Drugs, 2019 Non peer ...
openaire +4 more sources