Results 51 to 60 of about 210,600 (312)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Spatial and temporal changes of social vulnerability of cities to natural hazards in Zhejiang province, China

Heliyon
Understanding how social dynamics interact with natural hazards is one of the main challenges at global and local scales in the world for studying social vulnerability to natural hazards.
Shanzhong Qi, Shunli Hu, Shufen Cao
doaj   +1 more source

Societal Aspects of Vulnerability to Natural Hazards

Raumforschung und Raumordnung, 2012
To date, social vulnerability research has focused primarily on the individual and household levels, and on social institutions relevant to these two benchmarks.
Swen Zehetmair
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A theoretical and methodological essay on the concept of vulnerability / Un ensayo teórico y metodológico sobre el concepto de vulnerabilidad

Contexto: Revista de la Facultad de Arquitectura Universidad Autónoma de Nuevo León, 2018
This paper presents a bibliographical review on the concept and methods of identifying vulnerability in urban areas. From systematic bibliographic searches, the main concepts that orbit around vulnerability are defined, as well as their concretion ...
Antonio Palacios García, Pablo Mateos, Carmen Hidalgo Giralt   +2 more
doaj  

Measurement and impact analysis of social vulnerability to geological disasters in Guizhou Province, China

Scientific Reports
Investigating social vulnerability is a crucial aspect of attaining an in-depth understanding of disasters and disaster risk. This study developed a measurement framework for social vulnerability to geological disasters, obtained a comprehensive social ...
Yan Jia, Shuo Jia, Ruiqiu Pang
doaj   +1 more source

Pharmacy Accessibility and Social Vulnerability

JAMA Network Open
This cross-sectional study examines the association of availability of primary care practitioners and level of socioeconomic vulnerability with risk of pharmacy deserts in regions of the US.
Catalano, Giovanni, Khan, Muhammad Muntazir Mehdi, Chatzipanagiotou, Odysseas P., Pawlik, Timothy M.   +3 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mapping socio-ecological vulnerability of tropical peatland fires

Environmental Research Letters
Peatlands in Southeast Asia regularly experience fire due to clearance of forests and drainage for agriculture and plantation development. Fire represents a mainstay for rural communities managing tropical landscapes, but these can lead to uncontrolled ...
Janice Ser Huay Lee, Sifeng Wu, Yuti A Fatimah, Stuart W Smith, Nur Estya Bte Rahman, Kwek Yan Chong, Asmadi Saad, Budi Wardhana, Xingli Giam   +8 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source