Results 61 to 70 of about 1,036,478 (306)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Too poor to live? A case study of vulnerability and maternal mortality in Burkina Faso.
, 2013 This paper examines the concept of vulnerability in the context of maternal morbidity and mortality in Burkina Faso, an impoverished country in West Africa.
Drabo, Seydou +2 more
core +1 more source
Assessing the climate vulnerability of the world’s natural and cultural heritage [PDF]
, 2020 Climate change is the fastest-growing global threat to the world’s natural and cultural heritage. No systematic approach to assess climate vulnerability of protected areas and their associated communities has existed—until now.
Day, Jon C. +2 more
core
Exploitation, Vulnerability, and Social Domination
Philosophy & Public Affairs, 2013 This article attempts to revive a research program by criticizing it. Its object of criticism is the powerful research agenda of analytical Marxism. I shall attempt this revival by criticizing the views of two of the most influential members of that research program, G. A. Cohen and John Roemer.
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Contexto: Revista de la Facultad de Arquitectura Universidad Autónoma de Nuevo León, 2018 This paper presents a bibliographical review on the concept and methods of identifying vulnerability in urban areas. From systematic bibliographic searches, the main concepts that orbit around vulnerability are defined, as well as their concretion ...
Antonio Palacios García +2 more
doaj
HeliyonUnderstanding how social dynamics interact with natural hazards is one of the main challenges at global and local scales in the world for studying social vulnerability to natural hazards.
Shanzhong Qi, Shunli Hu, Shufen Cao
doaj +1 more source
Pharmacy Accessibility and Social Vulnerability
JAMA Network OpenThis cross-sectional study examines the association of availability of primary care practitioners and level of socioeconomic vulnerability with risk of pharmacy deserts in regions of the US.
Catalano, Giovanni +3 more
openaire +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source