Results 141 to 150 of about 1,851,219 (356)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Assessing Children’s Access to Speech Therapy Services During the COVID-19 Pandemic: A Qualitative Study [PDF]

open access: yesJournal of Rehabilitation
Objective Given the global emergence of the COVID-19 pandemic, notably in Iran, implementing preventive measures and protocols has constrained the accessibility of rehabilitation services, such as speech therapy.
Marzieh Takaffoli   +5 more
doaj  

Psychosocial and Health Effects of the COVID-19 Pandemic Experienced by Staff Employed in Social Welfare Facilities in Poland and Spain. [PDF]

open access: yesInt J Environ Res Public Health, 2023
Janus E   +4 more
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

open access: yesFEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu   +6 more
wiley   +1 more source

Designing and verifying an instrument to measure religiosity

open access: yesپژوهش در دین و سلامت, 2019
For downloading the full-text of this article please click here. Background and Objective: In spite of the paramount importance of religion in human life, the definition of its domain, concepts, and components is subject to theoretical and ...
Hasan Shahmirzalou   +4 more
doaj  

CHANGES IN SOCIAL WELFARE IN SINGAPORE - 1982-1999 [PDF]

open access: yes
This paper examines the changes in social welfare in Singapore using Labour Force Survey data. To study the changes and dominance, both ordinal and cardinal measures are used.
Pundarik Mukhopadhaya
core  

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

open access: yesFEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa   +13 more
wiley   +1 more source

Investigating the Requirements for Integration of the Social Determinants of Health Approach in Rehabilitation Education: A Qualitative Study in Iran [PDF]

open access: yesJournal of Rehabilitation
Objective Studies have examined social accountability in medical education in Iran, while no studies have deeply focused on social determinants of health, specifically for rehabilitation sciences.
Meroe Vameghi   +4 more
doaj  

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