Results 81 to 90 of about 1,851,219 (356)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Anthropometric Study of Paraplegic Wheelchair Users in Tehran

open access: yesطب جانباز, 2013
Background: Anthropometry is the science of measuring various dimensions of body and use of information obtained in determining the shape and size of workplace and tools used in various fields of industry, education and daily life.
A. Davudian Talab   +3 more
doaj  

Proposal to Strenghern Health Information System [HIS] [PDF]

open access: yes
\ud The HMIS Program described in this document aims at improving and strengthening the current Health Management Information System (HMIS) in Tanzania, known as MTUHA.
Ministry of Health and Social Welfare, (MoHSW)
core  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

A Critical Evaluation Of Traditional African Family System And Contemporary Social Welfare [PDF]

open access: yes, 2019
Beyond reasonable doubt, the influence of Western culture and civilizations has enervated traditional African family systems, and their functions as providers of social welfare.
Duke, Emmanuel Orok   +1 more
core  

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