Results 81 to 90 of about 1,819,903 (248)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Rehabilitation, 2010 Objective: Many researchers believe hearing impaired people suffer from special disability in metaphor comprehension. This study was aimed to compare the comprehension of metaphoric expressions in mainstreaming sever hearing impaired and normal students ...
Reyhaneh Mohammadi +4 more
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Designing a Valid & Reliable Tool for Assessing the Occupational Therapist\'s Clinical Competency
Journal of Rehabilitation, 2014 Objective: The aim of study was to design a valid and reliable tool for assessing the occupational therapists’ clinical competency. Materials & Methods: It was a tool-making study.
Azadeh Jabbari +4 more
doaj
Introduction to social choice and welfare [PDF]
Social choice theory is concerned with the evaluation of alternative methods of collective decision-making, as well as with the logical foundations of welfare economics.
Kotaro Suzumura
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Tax competition and income inequality : why did the welfare state survive? [PDF]
, 2012 Contrary to the belief of many, tax competition did not undermine the foundations of the welfare state and did not even abolish the taxation of capital.
Plümper, Thomas, Troeger, Vera
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Corruption Perception and Perceived Social Justice: upgrading the Administrative Integrity of Organizations and Improving the Citizens\' Perceived Justice [PDF]
مسائل اجتماعی ایران, 2016 The aim of this study is to examine the relationship between Perception of corruption and perceived social justice. This study is a cross-sectional survey. The target population was all Tehran residents, aged 18 to 60.
Mehdi Mohammadi +3 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source