Results 91 to 100 of about 15,402,540 (312)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Role of Education in the Development of Public Relations in the Modern Russia

open access: yesÈkonomika, Pedagogika i Pravo, 2016
In this article author showed influence of an education system on forming and development of public relations. The important role of education in the course of forming of civil society is noted.
Lubov I. Rogaceva
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Basic Issues of Management in the Field of Public Security

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2016
The issue of management in the area of public security is a subject under intensive research due to its importance for managing the security of the state.
Wojciech Wiśniewski
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

MUHASEBECİLİK MESLEĞİNİN TOPLUMDA ALGILANMA BİÇİMİÜZERİNE BİR ARAŞTIRMA

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2004
Mesleklerin gelişmesi ile toplumda ne kadar tanındıklarıarasında doğrusal bir ilişki bulunmaktadır. Bu bağlamda muhasebecilik mesleğinin de toplumda nasıl tanındığı, bilindiği ve değerlendirildiği bu mesleğin gelişmesinde önemli bir yer tutar.
Mikail Altan
doaj  

Harris County Medical Society, Woman\u27s Auxiliary Year Book 1926-1927 [PDF]

open access: yes, 1926
Partnering with the Texas Medical Association Alliance to improve the health of all Texans, the Harris County Medical Society (HCMS) Alliance was organized in 1919 as the HCMS Woman’s Auxiliary. Current membership consists of the spouses of physicians,
Harris County Medical Society, Woman\u27s Auxiliary
core   +1 more source

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