Results 91 to 100 of about 21,259,966 (304)

Basic Issues of Management in the Field of Public Security

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2016
The issue of management in the area of public security is a subject under intensive research due to its importance for managing the security of the state.
Wojciech Wiśniewski
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Indiana Historical Society Constitution

open access: yes
Those signing the constitution for the IHS included such notable local citizens as Calvin Fletcher, William Conner, John Tipton, David Wallace, Noah Noble, and John DePauw.
Indiana Historical Society
core  

MUHASEBECİLİK MESLEĞİNİN TOPLUMDA ALGILANMA BİÇİMİÜZERİNE BİR ARAŞTIRMA

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2004
Mesleklerin gelişmesi ile toplumda ne kadar tanındıklarıarasında doğrusal bir ilişki bulunmaktadır. Bu bağlamda muhasebecilik mesleğinin de toplumda nasıl tanındığı, bilindiği ve değerlendirildiği bu mesleğin gelişmesinde önemli bir yer tutar.
Mikail Altan
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

United States and containing of adversaries: Buck-Passing framework [PDF]

open access: yesFaṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat, 2013
John Mearsheimer believes that great powers used two mains strategies in offensive realism to Contain and control the enemies and rivals. 1) Balance 2) controlling rivals through Buck-Passing. The author attemptsto show examples of United States’ efforts
Ali Adami, Majid Dashtgerd
doaj  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

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