Results 111 to 120 of about 18,424,379 (354)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An investigation of factors influencing an organisation's intention to adopt cloud computing [PDF]
, 2014 Alkhater, Nouf +2 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Horizonte, 2011 Através de algumas considerações de caráter teológico, pretendemos mostrar que a festa da Virgem Maria de Guadalupe tem profundo enraizamento no coração do povo de Deus, por duas razões fundamentais: Primeiro: a devoção à "Guadalupana" nos remete à ...
Pedro Alarcon Mendez
doaj
United States and containing of adversaries: Buck-Passing framework [PDF]
Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat, 2013 John Mearsheimer believes that great powers used two mains strategies in offensive realism to Contain and control the enemies and rivals. 1) Balance 2) controlling rivals through Buck-Passing. The author attemptsto show examples of United States’ efforts
Ali Adami, Majid Dashtgerd
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source