Intragenic regulation of SOCS3 isoforms [PDF]
Cell Communication and Signaling, 2019 Background Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short and long isoform.
Oliver Klepsch +5 more
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Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model [PDF]
Lupus Science and Medicine, 2021 Objective Recently, podocytes have been recognised not only as a physical barrier to prevent urinary protein loss but also as producers of proinflammatory cytokines.
Taro Iwamoto +18 more
doaj +2 more sources
SOCS3 as a potential driver of lung metastasis in colon cancer patients [PDF]
Frontiers in Immunology, 2023 BackgroundThe suppressor of cytokine signaling 3 (SOCS3) is the negative feedback regulator of the JAK-STAT signaling pathway. The purpose of our study was to investigate the SOCS3 status in colon primary tumor and lung metastasis and its relationship ...
Xuejie Li +7 more
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SOCS3: An Immunological Biomarker Offering Potential Therapeutic Targets for Malignant Tumors [PDF]
Biological Procedures OnlineSuppressor of Cytokine Signaling 3 (SOCS3) is a critical regulator of cytokine signaling, primarily acting through the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway.
Yan Zhang +4 more
doaj +2 more sources
Correction: SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation [PDF]
The Journal of Immunology, 2016 Qin, H., A. T. Holdbrooks, Y. Liu, S. L. Reynolds, L. L. Yanagisawa, and E. N. Benveniste. 2012. SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J . Immunol . 189: [3439–3448][1].
Hongwei Qin +5 more
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Frontiers in Immunology, 2018 Objective: Despite extensive studies, the precise mechanism underlying spondyloarthritis, especially ankylosing spondylitis, remains elusive. This study aimed to develop an ideal animal model for an insight into mechanism of spondyloarthritis and ...
Yuhai Chen +17 more
doaj +2 more sources
Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells [PDF]
BMC NephrologyBackground In acute kidney injury (AKI), inflammatory crosstalk between tubular epithelial cells (TECs) and immune cells drives disease progression.
Xin Kang +4 more
doaj +2 more sources
STAT3 and SOCS3 expression patterns during murine placenta development
European Journal of Histochemistry, 2013 Signal transducers and activators of transcription 3 (Stat3) has been identified as an important signal transducer in the invasive phenotype of the trophoblasts cells in in vitro studies. However, the in situ distribution and patterns of expression of this molecule in trophoblast cells during the development of the placenta are still under-elucidated ...
Sebastián San Martín +6 more
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PCV2 Infection Upregulates SOCS3 Expression to Facilitate Viral Replication in PK-15 Cells [PDF]
VirusesPorcine circovirus type 2 (PCV2) is a globally prevalent swine pathogen that induces immunosuppression, predisposing pigs to subclinical infections. In intensive farming systems, PCV2 persistently impairs growth performance and vaccine efficacy, leading ...
Yiting Li +10 more
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