Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model [PDF]
Lupus Science and Medicine, 2021 Objective Recently, podocytes have been recognised not only as a physical barrier to prevent urinary protein loss but also as producers of proinflammatory cytokines.
Taro Iwamoto +18 more
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SOCS3 as a potential driver of lung metastasis in colon cancer patients [PDF]
Frontiers in Immunology, 2023 BackgroundThe suppressor of cytokine signaling 3 (SOCS3) is the negative feedback regulator of the JAK-STAT signaling pathway. The purpose of our study was to investigate the SOCS3 status in colon primary tumor and lung metastasis and its relationship ...
Xuejie Li +7 more
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SOCS3: An Immunological Biomarker Offering Potential Therapeutic Targets for Malignant Tumors [PDF]
Biological Procedures OnlineSuppressor of Cytokine Signaling 3 (SOCS3) is a critical regulator of cytokine signaling, primarily acting through the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway.
Yan Zhang +4 more
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Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells [PDF]
BMC NephrologyBackground In acute kidney injury (AKI), inflammatory crosstalk between tubular epithelial cells (TECs) and immune cells drives disease progression.
Xin Kang +4 more
doaj +2 more sources
PCV2 Infection Upregulates SOCS3 Expression to Facilitate Viral Replication in PK-15 Cells [PDF]
VirusesPorcine circovirus type 2 (PCV2) is a globally prevalent swine pathogen that induces immunosuppression, predisposing pigs to subclinical infections. In intensive farming systems, PCV2 persistently impairs growth performance and vaccine efficacy, leading ...
Yiting Li +10 more
doaj +2 more sources
Frontiers in Immunology, 2018 Objective: Despite extensive studies, the precise mechanism underlying spondyloarthritis, especially ankylosing spondylitis, remains elusive. This study aimed to develop an ideal animal model for an insight into mechanism of spondyloarthritis and ...
Yuhai Chen +17 more
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Role of suppressors of cytokine signaling (SOCS) 3 in bone inflammatory responses [PDF]
Frontiers in Immunology, 2014 Suppressor of cytokine signaling 3 (SOCS3) is a potent regulator of cytokine signaling in macrophages and T cells. In recent studies, evidence has been provided for SOCS3 activation in all major bone cells including osteoclasts, chondrocytes ...
Anqi eGao, Thomas Elliott Van Dyke
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A Clinical Predictive Model Based on SOCS3 Promoter Methylation to Predict the Prognosis of Acute-on-Chronic Hepatitis B Liver Failure [PDF]
Journal of Inflammation ResearchJi-Hui Li,1 Yuna Tang,1 Jing Wang,1 Xue-Fei Wei,1 Na Wang,2 Jing-Wei Wang,2 Hui Lyu,3 Xue-Mei Jiang,4 Hui-Hui Liu,1,5 Kai Wang1,5,6 1Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 2Department ...
Li JH +9 more
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SOX6-SOCS3 regulates hypoxia-induced proliferation of HPASMCs by targeting STAT3 signaling pathway
Di-san junyi daxue xuebao, 2021 Objective To investigate the role of SRY-Box transcription factor 6 (SOX6)-suppressor of cytokine signaling 3 (SOCS3) on hypoxia-induced proliferation of human pulmonary artery smooth muscle cells (HPASMCs) and explore the possible mechanism.
WANG Yu +4 more
doaj +1 more source
Socs3b regulates the development and function of innate immune cells in zebrafish
Frontiers in Immunology, 2023 IntroductionSuppressor of cytokine signaling 3 (SOCS3) is a critical component of the negative feedback regulation that controls signaling by cytokines and other factors thereby ensuring that important processes such as hematopoiesis and inflammation ...
Mohamed L. Sobah +7 more
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