Results 131 to 140 of about 35,106 (263)

Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/Thrombocythemia

Turkish Journal of Hematology, 2013
OBJECTIVE: Myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are acquired clonal hematopoietic stem cell disorders and originate from a multipotent hematopoietic stem cell ...
Deniz Torun, Oral Nevruz, Mesut Akyol, Salih Kozan, Muhterem Bahçe, Şefik Güran, Cengiz Beyan   +6 more
doaj   +1 more source

Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]

, 2019
Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav, Eckalbar, Walter L, Inoue, Fumitaka, Matharu, Navneet, Murphy, Karl K, Vaisse, Christian, Wang, Yi   +6 more
core   +1 more source

Network and Gene Set Enrichment Analysis of Adipokine Drivers of Prostate Cancer; Unravelling the Mechanistic Link Between Excess Adiposity and Prostate Cancer Risk

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Adiposity‐Based Chronic Disease (ABCD), a novel model housing obesity, insulin resistance, and adipokine‐related inflammation, increases the risk of aggressive prostate cancer (PCa), posttreatment PCa recurrence, and PCa mortality. This paper provides a new network analysis of relevant metabolic drivers to provide insight into the ...
Zachary Dovey, Elena Tomas Bort, Jeffrey I. Mechanick   +2 more
wiley   +1 more source

Identifying differentially expressed genes in goat mammary epithelial cells induced by overexpression of SOCS3 gene using RNA sequencing

Frontiers in Veterinary Science
The suppressor of cytokine signaling 3 (SOCS3) is a key signaling molecule that regulates milk synthesis in dairy livestock. However, the molecular mechanism by which SOCS3 regulates lipid synthesis in goat milk remains unclear.
Ning Song, Cunxia Ma, Yuzhu Guo, Shuangshuang Cui, Shihao Chen, Zhi Chen, Yinghui Ling, Yunhai Zhang, Hongyu Liu   +8 more
doaj   +1 more source

microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling

Cancer Management and Research, 2021
Zhenkun Yan,1 Sen Hong,2 Yumei Song,3 Miaomiao Bi4 1Department of Endoscopy Center, The Third Hospital of Jilin University, Changchun, Jilin, 130022, People’s Republic of China; 2Department of Colorectal and Anal Surgery, The First Hospital of ...
Yan Z, Hong S, Song Y, Bi M
doaj  

EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA

Медицинская иммунология, 2016
Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR.
V. V. Lim, V. A. Ivanov, L. N. Sorokina, V. N. Mineev, M. A. Nyoma, V. I. Trofimov   +5 more
doaj   +1 more source

Suppressor of Cytokine Signaling (SOCS)1 and SOCS3 Stimulation during Experimental Cytomegalovirus Retinitis: Virologic, Immunologic, or Pathologic Mechanisms

, 2022
Christine I. Alston
openalex   +2 more sources

Higher pNRF2, SOCS3, IRF3, and RIG1 Tissue Protein Expression in NASH Patients versus NAFL Patients: pNRF2 Expression Is Concomitantly Associated with Elevated Fasting Glucose Levels [PDF]

, 2023
Suzan Schwertheim, Malek Alhardan, Paul Manka, Jan‐Peter Sowa, Ali Canbay, Hartmut Schmidt, Hideo A. Baba, Julia Kälsch   +7 more
openalex   +1 more source

New Insights Into Ginseng and Clove Supplementation: Alleviating Obesity by Reducing Leptin Resistance and Reshaping the Gut Microbiota

Food Frontiers, Volume 7, Issue 1, January 2026.
AEGC conferred substantial resistance to weight gain and reduced food intake. AEGC may alleviate LR by regulating the levels of LEP and ADP. AEGC elevated the diversity of gut microbiota and reconstructed the composition. Changes such as CAG‐873 in gut microbiota may be the reason why AEGC alleviates LR.
Weifeng Ni, Shen Yao, Shichao Li, Shichao Liu, Liwei Sun, Daqing Zhao, Zhengqi Dong, Siming Wang, Weinan Wang, Meichen Liu   +9 more
wiley   +1 more source

Threshold Effects of Maternal Vitamin C in Late Pregnancy on Infant Social Competence: A Nonlinear Dose‐Response Analysis in a Birth Cohort

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This prospective cohort study analysing 442 mother‐offspring pairs reveals a nonlinear dose‐response relationship between late‐pregnancy serum vitamin C concentration and early offspring social competence. The strongest association was observed at low concentrations (≤ 4.9 μmol/L, β = 0.654/μmol), with diminishing effects at moderate levels (4.9–49 ...
Cui Li, Ji Jiafen, Ni Juan, Li Rui xiang
wiley   +1 more source