Results 141 to 150 of about 35,106 (263)
Glia, Volume 74, Issue 1, January 2026.Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao +9 more
wiley +1 more source
Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing [PDF]
, 2016 Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine ...
Feng, Yi +5 more
core +1 more source
Health Science Reports, Volume 9, Issue 1, January 2026.ABSTRACT Background and Aims Ulcerative colitis (UC), a chronic inflammatory bowel disease, causes persistent mucosal inflammation and epithelial dysfunction. Basal progenitor cells (BPCs), critical for intestinal regeneration and mucosal repair, exhibit altered behavior in UC.
Xiaopeng Chen +9 more
wiley +1 more source
Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression [PDF]
, 2018 Hsin Chien +2 more
openalex +1 more source
Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.In a mouse model of spinal cord injury, pharmacological inhibition of EZH2 with GSK‐343 reduces tissue damage and neuronal demyelination. GSK‐343 suppresses the EZH2/TRAF6/NF‐κB signaling pathway, leading to attenuation of neuroinflammation and innate immune activation. These effects promote early neuroprotection and improved locomotor recovery in vivo.
Yinhui Kang +9 more
wiley +1 more source
Supplementary Figure 4 from Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3 [PDF]
, 2023 Burkhard Kneitz +12 more
openalex +1 more source
The Role of Macrophages in Cancer: From Basic Research to Clinical Applications
MedComm, Volume 7, Issue 1, January 2026.Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu +5 more
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 1, January 2026.This study reveals that Lactobacillus salivarius Li01 alleviates acute pancreatitis by increasing gut Paramuribaculum. This modulation of the microbiota and its steroid hormone metabolites suppresses the pancreatic TNF signaling pathway, uncovering a protective ‘gut‐metabolism‐immunity’ axis.
Jiamin Duan +5 more
wiley +1 more source