Evaluation of leptin treatment on maintenance of body weight loss in diet‐induced obese mice
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 401-416, January 2026.Abstract Aims To evaluate the therapeutic potential of leptin treatment for weight loss maintenance preclinically, through a systematic evaluation of leptin efficacy (a) following a period of weight loss stability (as in published clinical studies), and (b) across a range of circulating leptin concentrations achieved through a variety of different ...
Danna M. Breen +9 more
wiley +1 more source
Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy
The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro +2 more
wiley +1 more source
Frontiers in ImmunologyBackgroundThe family of Suppressor of Cytokine Signaling (SOCS) acts as a controller of the duration and intensity of cytokine function by negatively regulating the JAK-STAT signaling pathway.
Mariaenrica Tinè +18 more
doaj +1 more source
SOCS3 is a novel bi-functional regulator of muscle growth and wasting [PDF]
, 2015 poster abstractDisease states such as cancer and other inflammatory conditions often show elevated IL-6 levels that correlate with muscle wasting and mortality.
Au, Ernie D. +6 more
core
Inflammatory Response as a Mechanism of Perinatal Programming: Long-term Impact on Pulmonary and Renal Function? [PDF]
, 2012 RATIONALE: Temporal changes in the fetal environment, such as malnutrition and placental insufficiency induce intrauterine growth restriction (IUGR) and lead to a permanent changes of physiological processes later in life.
Alejandre Alcázar, Miguel Angel
core
Impaired Interleukin-12-Dependent T-Cell Functions During Aging: Role of Signal Transducer and Activator of Transcription 4 (STAT4) and Suppressor of Cytokine Signaling 3 (SOCS3) [PDF]
, 2006 Cosimo Tortorella +6 more
openalex +1 more source
SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling [PDF]
, 2016 Cong Li +9 more
openalex +1 more source
LncGBP9/miR-34a axis modulates macrophage M1/M2 polarization to affect spinal cord injury repair via STAT1/STAT6 and SOCS3 [PDF]
, 2019 Jiahui Zhou +5 more
openalex +1 more source
Exosomes-Transferred Socs3 Inhibits DCS Activity In OSCC
International Dental JournalAim or purpose: This study aims to figure out the role of SOCS3 in OSCC progression and investigate its potential regulatory mechanisms on dendritic cells, which are responsible for initiating and modulating adaptive immune responses.
Xuanyu Zhang
doaj +1 more source