SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation [PDF]
The Journal of Immunology, 2012 Abstract Macrophages participate in both the amplification of inflammation at the time of injury and downregulation of the inflammatory response to avoid excess tissue damage. These divergent functions of macrophages are dictated by their microenvironment, especially cytokines, which promote a spectrum of macrophage phenotypes.
Hongwei Qin +5 more
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SOCS3 is a modulator of human macrophage phagocytosis [PDF]
Journal of Leukocyte Biology, 2016 ACKNOWLEDGMENTS This work was supported by Kidney Research UK (Grant Number RP1/2012). The authors thank the staff of the Aberdeen Microscopy and Histology Core Facility for advice and technical assistance. The authors acknowledge and are grateful to all
Erwig, Lars P +4 more
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Role of suppressors of cytokine signaling (SOCS) 3 in bone inflammatory responses [PDF]
Frontiers in Immunology, 2014 Suppressor of cytokine signaling 3 (SOCS3) is a potent regulator of cytokine signaling in macrophages and T cells. In recent studies, evidence has been provided for SOCS3 activation in all major bone cells including osteoclasts, chondrocytes ...
Anqi eGao, Thomas Elliott Van Dyke
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NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer. [PDF]
Cell Death DisTang Y +11 more
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SOX6-SOCS3 regulates hypoxia-induced proliferation of HPASMCs by targeting STAT3 signaling pathway
Di-san junyi daxue xuebao, 2021 Objective To investigate the role of SRY-Box transcription factor 6 (SOX6)-suppressor of cytokine signaling 3 (SOCS3) on hypoxia-induced proliferation of human pulmonary artery smooth muscle cells (HPASMCs) and explore the possible mechanism.
WANG Yu +4 more
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Socs3b regulates the development and function of innate immune cells in zebrafish
Frontiers in Immunology, 2023 IntroductionSuppressor of cytokine signaling 3 (SOCS3) is a critical component of the negative feedback regulation that controls signaling by cytokines and other factors thereby ensuring that important processes such as hematopoiesis and inflammation ...
Mohamed L. Sobah +7 more
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Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. [PDF]
PLoS ONE, 2012 Suppressor of cytokine signaling 3 (SOCS3) is an inducible endogenous negative regulator of signal transduction and activator of transcription 3 (STAT3). Epigenetic silencing of SOCS3 has been shown in head and neck squamous cell carcinoma (HNSCC), which
Carlos Rossa +5 more
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A Review on the Dual Role of SOCS3 in Cancer [PDF]
Research in Oncology, 2022 Background: Aberrant proliferation is a hallmark of cancer. Cellular proliferation mechanisms and various cytokines contribute to the progression of cancer.
Rajdeep Chakraborty +4 more
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JAK-STAT, 2012 The suppressors of cytokine signaling (SOCS) family of proteins are cytokine-inducible inhibitors of Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) signaling pathways. Among the family, SOCS1 and SOCS3 potently suppress cytokine actions by inhibiting JAK kinase activities.
Yasukawa, Hideo +3 more
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AntagomiR-19a Induced Better Responsiveness to Bortezomib in Myeloma Cell Lines [PDF]
Cell Journal, 2021 Objective: Multiple myeloma (MM) is the clonal proliferation of neoplastic plasma cells in the bone marrow. Although bortezomib (BTZ) is a crucial drug for the treatment of MM, drug resistance is a major problem.
Azam Kazemi +2 more
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