Results 251 to 260 of about 35,106 (263)

SOCS3 Phosphorylation In Myeloproliferative Neoplasms

Blood, 2010
Abstract Abstract 3083 Introduction: Suppressor of cytokine signaling protein 3 (SOCS3) is an important regulator of the erythropoietin receptor and the receptor-associated JAK2 kinase.
Arnold, C., Elliott, J., Johnston, James, McMullin, Mary Frances   +3 more
openaire   +1 more source

Training, Leptin Receptors and SOCS3 in Human Muscle

International Journal of Sports Medicine, 2011
Endurance exercise induces SUPPRESSOR of CYTOKINE SIGNALING 3 (SOCS3) mRNA expression in rodent skeletal muscle and endurance training overimposed on strength training blunts the hypertrophic response to strength training by an unknown mechanism. The aim of this study was to determine the effects of a concurrent strength and endurance training on fat ...
Olmedillas, H., Guerra, B., Guadalupe-Grau, A., Santana, A., Fuentes, T., Dorado, C., Serrano-Sanchez, J. A., Calbet, J. A. L.   +7 more
openaire   +3 more sources

SOCS3 in Liver Regeneration and Hepatocarcinoma

Molecular Interventions, 2008
Cytokine responses are stringently controlled by a family of proteinsSTAT3 termed the suppressors of cytokine signaling (SOCS), and deregulation of SOCS function is associated with many diseases, including several cancers, disorders in hematopoiesis, and autoimmune diseases.
openaire   +3 more sources

SOCS3 negatively regulates IL-6 signaling in vivo

Nature Immunology, 2003
Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the liver or in macrophages.
Croker, Ben A., Krebs, Danielle L., Zhang, Jian-Guo, Wormald, Sam, Willson, Tracy A., Stanley, Edouard G., Robb, Lorraine, Greenhalgh, Christopher J., Forster, Irmgard, Clausen, Bjorn E., Nicola, Nicos A., Metcalf, Donald, Hilton, Douglas J., Roberts, Andrew W., Alexander, Warren S.   +14 more
openaire   +4 more sources

Inhibitory DNA Aptamer Tools against SOCS3-gp130 Interactions

ACS Applied Materials & Interfaces
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a crucial role in transmembrane signal transduction, enabling cells to communicate with the extracellular environment, which requires precise regulation to prevent abnormal signaling outcomes.
Xinna Zhang, Yu Hou, Weichang Chen, Ting Fu, Yong Wei, Weihong Tan   +5 more
openaire   +2 more sources

Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

Nature Medicine, 2005
Suppressor of cytokine signaling (SOCS) 3 attenuates proinflammatory signaling mediated by the signal transducer and activator of transcription (STAT) family of proteins. But acute inflammation can occur after exposure to pathogen-derived inducers staphylococcal enterotoxin B (SEB) and lipopolysaccharide (LPS), or the lectin concanavalin A (ConA ...
Daewoong, Jo, Danya, Liu, Shan, Yao, Robert D, Collins, Jacek, Hawiger   +4 more
openaire   +2 more sources

SOCS3 negatively regulates LIF signaling in neural precursor cells

Molecular and Cellular Neuroscience, 2006
Cytokines that signal through the LIFRbeta/gp130 receptor complex, including LIF and CNTF, promote the self-renewal of embryonic and adult neural precursor cells (NPCs). In non-CNS tissues, the protein suppressor of cytokine signaling-3 (SOCS3) negatively regulates signaling through gp130.
Emery, B., Merson, T. D., Snell, C., Young, K. M., Ernst, M., Kilpatrick, T. J.   +5 more
openaire   +3 more sources

SOCS3 as a future target to treat metabolic disorders

Hormones, 2018
The suppressors of cytokine signaling (SOCS) are a group of eight proteins responsible for preventing excessive cytokine signaling. Among this protein family, SOCS3 has received special attention. SOCS3 expression is important to control certain allergy autoimmune diseases.
João A.B. Pedroso, Angela M. Ramos-Lobo, Jose Donato   +2 more
openaire   +2 more sources

Functional redundancy of SOCS3

Cytokine, 2009
H. Kiu, A.W. Roberts, W.S. Alexander
openaire   +1 more source

SOCS3/JAK2/STAT3 pathway in iPSCs

2022
Ruifan Wu, Xinxia Wang
openaire   +1 more source