Results 21 to 30 of about 35,106 (263)
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology [PDF]
, 2020 Gestational diabetes (GDM) is among the most challenging diseases in westernized countries, affecting mother and child, immediately and in later life. Obesity is a major risk factor for GDM.
Henrich, Wolfgang +6 more
core +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. [PDF]
PLoS Pathogens, 2013 Suppressor of cytokine signalling 3 (SOCS3) negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens.
Berit Carow +7 more
doaj +1 more source
Molecular Immunology, 2020 Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether deletion of Socs3 in the lung epithelial cells would affect influenza lung replication and inflammation in vivo is unknown.
Ling, Li +6 more
openaire +2 more sources
Promotion of Erythropoietic Differentiation in Hematopoietic Stem Cells by SOCS3 Knock-Down. [PDF]
PLoS ONE, 2015 Suppressor of cytokine signaling 3 (SOCS3) plays an important role in mice fetal liver erythropoiesis, but the roles of SOCS3 in human hematopoietic stem cells (HSCs) have not been well investigated.
Yu-xiao Liu +9 more
doaj +1 more source
SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection
Frontiers in Cellular and Infection Microbiology, 2021 Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and neoplastic diseases in poultry. Cytokine signal-transduction inhibitor molecule 3 (SOCS3) is an important negative regulator of the JAK2/STAT3 signaling ...
Guodong Mo +18 more
doaj +1 more source
Regulating the regulators: SOCS3 joins the dance [PDF]
Annals of the Rheumatic Diseases, 2011 Invariant natural killer T (iNKT) cells belong to a prototypical regulatory T cell lineage that functions at the interface of innate immunity and adaptive immunity. Unlike peptide-restricted T cells, iNKT cells recognise and respond to various glycolipid antigens presented in the context of the major histocompatibility complex class I-like molecule ...
Michael, Drennan, Dirk, Elewaut
openaire +2 more sources
SOCS Proteins in Macrophage Polarization and Function [PDF]
, 2014 Peer reviewedPublisher ...
Wilson, Heather M
core +2 more sources
SOCS3 Silencing Attenuates Eosinophil Functions in Asthma Patients [PDF]
International Journal of Molecular Sciences, 2015 Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high levels of suppressor of cytokine signaling 3 (SOCS3).
Mª Zafra +10 more
openaire +4 more sources