Results 31 to 40 of about 34,469 (215)

SOCS3-Mediated Blockade Reveals Major Contribution of JAK2/STAT5 Signaling Pathway to Lactation and Proliferation of Dairy Cow Mammary Epithelial Cells in Vitro

Molecules, 2013
Suppressor of cytokine signaling 3 (SOCS3) is a cytokine-induced negative feedback-loop regulator of cytokine signaling. More and more evidence has proved it to be an inhibitor of signal transducers and activators of transcription 5 (STAT5).
Qing-Zhang Li, Xue-Jun Gao, Li Zhang, Zhe Sun, Yu Si, Xia Zhang, Feng Zhao, Chao-Chao Luo, Yu-Ling Huang   +8 more
doaj   +1 more source

Suppressor of Cytokine Signaling 3 (SOCS3) Degrades p65 and Regulate HIV-1 Replication

Frontiers in Microbiology, 2019
Human Immunodeficiency Virus-1 (HIV-1) is known to induce the expression of SOCS3 which is a negative feed-back regulator of inflammatory responses. Here, we demonstrate that reactivation of latent HIV-1 leads to degradation of SOCS3 at early time points.
Vikas Sood, Vikas Sood, Sneh Lata, Sneh Lata, Vishnampettai G. Ramachandran, Akhil C. Banerjea   +5 more
doaj   +1 more source

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P., Bozinovski, S., Ernst, M.R., Jarnicki, A.G., Jones, J., Knight, D.A., Lau, H.L., Laurent, G.J., McAnulty, R.J., McKenzie, B.S., Mutsaers, S.E., O'Donoghue, R.J.J., Prêle, C.M., Richards, C.D., Rose-John, S., Stumbles, P.A., Thiem, S., Vlahos, R., Wang, B., Zhu, H.J.   +19 more
core   +2 more sources

MiR-218-5p-dependent SOCS3 downregulation increases osteoblast differentiation inpostmenopausal osteoporosis

Journal of Orthopaedic Surgery and Research, 2023
Background Postmenopausal osteoporosis (POP) is a prevalent skeletal disease among elderly women. Previous study indicated that suppressor of cytokine signaling 3 (SOCS3) participates in the regulation of bone marrow stromal cell (BMSC) osteogenesis ...
Qian Zhou, Lihua Zhou, Jun Li
doaj   +1 more source

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources

Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3.

PLoS ONE, 2019
Glioblastoma multiforme (GBM) is a poor prognosis type of tumour due to its resistance to chemo and radiotherapy. SOCS1 and SOCS3 have been associated with tumour progression and response to treatments in different kinds of cancers, including GBM.
Maria Paz Ventero, Maria Fuentes-Baile, Cristina Quereda, Elizabeth Perez-Valeciano, Cristina Alenda, Pilar Garcia-Morales, Danilo Esposito, Pilar Dorado, Victor Manuel Barbera, Miguel Saceda   +9 more
doaj   +1 more source

MiR-124-3p/B4GALT1 axis plays an important role in SOCS3-regulated growth and chemo-sensitivity of CML

Journal of Hematology & Oncology, 2016
Background Abnormal expression of SOCS3 has been implicated in myeloproliferative neoplasms, but the role of SOCS3 in the pathogenesis of leukemia remains largely unknown.
Yu-xiao Liu, Li Wang, Wen-jia Liu, Hai-tao Zhang, Jing-hui Xue, Zhi-wen Zhang, Chun-ji Gao   +6 more
doaj   +1 more source

Trophoblast stem cells rescue placental defect in SOCS3-deficient mice [PDF]

, 2006
Stem cells have important clinical and experimental potentials. Trophoblast stem (TS) cells possess the ability to differentiate into trophoblast subtypes in vitro and contribute to the trophoblast lineage in vivo.
C. CRISTIE NAGY, DOMINICI, Massimo, J. N. IHLE, J. SWIFT, Y. TAKAHASHI   +4 more
core   +1 more source

Evolution of Th2 responses : Characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity [PDF]

, 2017
Acknowledgements This research was funded by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993 TARGETFISH). T.W.
A Antczak, A Bhattacharjee, A Munitz, AE Lockyer, E Wangkahart, EJ Song, F Buonocore, F Takizawa, G Biswas, G Scapigliati, H Nielsen, J Zhu, J Zou, JE Allen, JH Li, JW Hodgkinson, K Bao, K Tamura, L-y Zhu, LM Braden, M Howard, M Ohtani, M Tine, M Wills-Karp, MG Reese, MM Costa, MO Huising, N Nunez Ortiz, PJ Lupardus, RC Edgar, RL Coffman, S Almeria, S Kumar, S McCormick, SP Gadani, T Hage, T Maehr, T Wang, T Wang, T Wang, T Wang, T Yamaguchi, T Yamaguchi, TA Wynn, TA Wynn   +44 more
core   +1 more source

Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages

Respiratory Research, 2017
Background SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI).
Zhilong Jiang, Zhihong Chen, Liyang Li, Wenjun Zhou, Lei Zhu   +4 more
doaj   +1 more source