Results 41 to 50 of about 34,469 (215)
Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2018 Suppressor of cytokine signaling 3 (SOCS3) is involved in Bcr-Abl–induced tumorigenesis. However, how SOCS3 interacts with Bcr-Abl and is regulated by Abl kinases remains largely unknown.
Riyue Feng +8 more
doaj +1 more source
Virulence, 2021 Little is known about how Talaromyces marneffei, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system.
Wudi Wei +15 more
doaj +1 more source
A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts [PDF]
, 2013 Suppressor of cytokine signaling 3 (SOCS3) is a key regulator of cytokine signaling in macrophages and T cells. Although SOCS3 seems to contribute to the balance between the pro-inflammatory actions of IL-6 family of cytokines and anti-inflammatory ...
Gao, Anqi +4 more
core +2 more sources
Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]
, 2007 *Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky +17 more
core +3 more sources
Suppressor of Cytokine Signaling-3 (SOCS-3) induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) expression in hepatic HepG2 cell line [PDF]
, 2015 The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor (TNF-\u3b1).
Corsini, Alberto +7 more
core +2 more sources
Epigenetic silencing of SOCS3 expression contributes to fibrosis in Crohn’s disease [PDF]
, 2017 Identified risk polymorphisms affecting the Jak-STAT3 pathway in patients with Crohn’s disease could affect TGF-β1 and collagen I expression and in the pathway’s negative regulator, SOCS3.
Kuemmerle, John F +2 more
core +1 more source
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source
Advanced Healthcare Materials, EarlyView.A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao +6 more
wiley +1 more source
Advanced Science, EarlyView.BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan +13 more
wiley +1 more source
Advanced Science, EarlyView.In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo +19 more
wiley +1 more source