Results 41 to 50 of about 35,106 (263)

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway. [PDF]

, 2008
BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation.
A Herrmann, A Mahdavi, A Regev, A Regev, A Singh, A Verma, AD Sharrocks, Anna Dudka, B Alberts, C Priami, C Priami, Corrado Priami, D Gillespie, F Ciocchetta, I Lödige, I Swameye, J Bravo, J Fisher, J Heath, J ten Hoeve, John K Heath, K Rakesh, L Dematté, L Dematté, L Klampfer, M Calder, M Kwiatkowska, Maria Luisa Guerriero, ML Guerriero, ML Guerriero, ML Guerriero, N Underhill-Day, NC Reich, Nicholas Underhill-Day, P Heinrich, S Bhattacharya, T Yamamoto, WS Alexander   +37 more
core   +7 more sources

Construction and identification adenovirus of SOCS3 [PDF]

Heart, 2011
Objective To construct and identify the recombinant adenovirus containing SOCS3, detect SOCS3 expression level in HEK293 cells and provide valuable reference for gene therapy of myocarditis. Methods The SOCS3 gene was cloned by RT-PCR after total ...
Liang Xiao, He Ming, Chen Tao, Hui Zhiyan, Wu Yuliang   +4 more
openaire   +1 more source

FXR induces SOCS3 and suppresses hepatocellular carcinoma

Oncotarget, 2015
Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 (STAT3) activity. Farnesoid X Receptor (FXR), highly expressed in liver, has an important role in protecting against hepatocellular carcinoma (HCC).
Fei, Guo, Zhizhen, Xu, Yan, Zhang, Peng, Jiang, Gang, Huang, Shan, Chen, Xilin, Lyu, Ping, Zheng, Xin, Zhao, Yijun, Zeng, Shuguang, Wang, Fengtian, He   +11 more
openaire   +3 more sources

Suppressor of Cytokine Signaling 3 (SOCS3) Degrades p65 and Regulate HIV-1 Replication

Frontiers in Microbiology, 2019
Human Immunodeficiency Virus-1 (HIV-1) is known to induce the expression of SOCS3 which is a negative feed-back regulator of inflammatory responses. Here, we demonstrate that reactivation of latent HIV-1 leads to degradation of SOCS3 at early time points.
Vikas Sood, Vikas Sood, Sneh Lata, Sneh Lata, Vishnampettai G. Ramachandran, Akhil C. Banerjea   +5 more
doaj   +1 more source

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P., Bozinovski, S., Ernst, M.R., Jarnicki, A.G., Jones, J., Knight, D.A., Lau, H.L., Laurent, G.J., McAnulty, R.J., McKenzie, B.S., Mutsaers, S.E., O'Donoghue, R.J.J., Prêle, C.M., Richards, C.D., Rose-John, S., Stumbles, P.A., Thiem, S., Vlahos, R., Wang, B., Zhu, H.J.   +19 more
core   +2 more sources

SOCS3-Mediated Blockade Reveals Major Contribution of JAK2/STAT5 Signaling Pathway to Lactation and Proliferation of Dairy Cow Mammary Epithelial Cells in Vitro

Molecules, 2013
Suppressor of cytokine signaling 3 (SOCS3) is a cytokine-induced negative feedback-loop regulator of cytokine signaling. More and more evidence has proved it to be an inhibitor of signal transducers and activators of transcription 5 (STAT5).
Qing-Zhang Li, Xue-Jun Gao, Li Zhang, Zhe Sun, Yu Si, Xia Zhang, Feng Zhao, Chao-Chao Luo, Yu-Ling Huang   +8 more
doaj   +1 more source

MiR-124-3p/B4GALT1 axis plays an important role in SOCS3-regulated growth and chemo-sensitivity of CML

Journal of Hematology & Oncology, 2016
Background Abnormal expression of SOCS3 has been implicated in myeloproliferative neoplasms, but the role of SOCS3 in the pathogenesis of leukemia remains largely unknown.
Yu-xiao Liu, Li Wang, Wen-jia Liu, Hai-tao Zhang, Jing-hui Xue, Zhi-wen Zhang, Chun-ji Gao   +6 more
doaj   +1 more source

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]

, 2015
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam, Chang, Louise, Downes, Michael, Evans, Ronald M, Korytnaya, Evgenia, Krause, Danielle M, Liddle, Christopher, Lumeng, Carey N, Neidert, Adam, Oral, Elif A, Peng, Xiaoling, Poirier, BreAnne, Reilly, Shannon M, Saltiel, Alan R, Uhm, Maeran, Yu, Ruth T, Zamarron, Brian F   +16 more
core   +2 more sources

Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3.

PLoS ONE, 2019
Glioblastoma multiforme (GBM) is a poor prognosis type of tumour due to its resistance to chemo and radiotherapy. SOCS1 and SOCS3 have been associated with tumour progression and response to treatments in different kinds of cancers, including GBM.
Maria Paz Ventero, Maria Fuentes-Baile, Cristina Quereda, Elizabeth Perez-Valeciano, Cristina Alenda, Pilar Garcia-Morales, Danilo Esposito, Pilar Dorado, Victor Manuel Barbera, Miguel Saceda   +9 more
doaj   +1 more source

Socs3 induction by PPARγ restrains cancer-promoting inflammation [PDF]

Cell Cycle, 2013
The presence of proinflammatory cytokines in the tumor microenvironment can support further growth of established cancers. Docosahexaenoic acid (DHA), a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand, has been shown to suppress inflammation and limit tumor progression in vivo. Are the anticancer properties of DHA relying on its ability
Végran, Frédérique, Berger, Hélène, Ghiringhelli, François, Apetoh, Lionel   +3 more
openaire   +2 more sources