Results 81 to 90 of about 34,469 (215)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Pengaruh Variasi Jumlah Tembakan Nanosecond Pulsed Electric Fields (Nspefs) Terhadap Ekspresi Gen Socs3 pada Sel Kanker Serviks Hela S3

JRST: Jurnal Riset Sains dan Teknologi, 2017
Abstrak Nanosecond Pulsed Electric Fields (NsPEFs) merupakan teknologi bioelektrik yang berkembang dari teknologi elektroporasi. NsPEFs diberikan dengan intensitas tinggi namun dalam waktu yang sangat singkat yaitu 1 - 300 nanosekon.
Martina Kurnia Rohmah
doaj   +1 more source

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]

, 2019
Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous, Arosio, Paolo, Asperti, Michela, Denardo, Andrea, Esko, Jeffrey D, Gordts, Philip LSM, Gryzik, Magdalena, Poli, Maura, Ruzzenenti, Paola   +8 more
core  

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]

, 2015
The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri, Alshaker, Heba, Muhammad, Aun, Pchejetski, Dmitri, Sacco, Keith, Winkler, Mathias   +5 more
core   +2 more sources

The Nutrigenomic Effect of Mela Rosa Marchigiana Callus Extract on Cellular Senescence: Insight From a Preliminary In Vitro Study

Molecular Nutrition &Food Research, EarlyView.
Mela Rosa Marchigiana (MRM) is an ancient apple variety peculiar of the center of Italy. The in vitro culture of the MRM pulp explants leaded to the production of calluses whose ethanolic extract has been suggested to be rich in pentacyclic triterpenic acids.
Chiara Rucci, Enrica Sordini, Giuseppe Persico, Eugenia Ciurlia, Noemi Pappagallo, Giulia Matacchione, Marco Giorgio, Daniele Fraternale, Maria Cristina Albertini, Dale Annear, Peter De Rijk, Tim De Pooter, Mojca Strazisar, Wim Vanden Berghe, Laura Bordoni, Stefano Amatori, Rosita Gabbianelli   +16 more
wiley   +1 more source

EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA

Медицинская иммунология, 2016
Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR.
V. V. Lim, V. A. Ivanov, L. N. Sorokina, V. N. Mineev, M. A. Nyoma, V. I. Trofimov   +5 more
doaj   +1 more source

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease [PDF]

, 2008
© 2008 Zhu et al. This article is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).Maintaining tolerance of T cells to self-antigens
Kioussis, Dimitris, Li, Suling, Martin, Joanne E., Symonds, Alistair L.J., Wang, Ping, Wraith, David C., Zhu, Bo   +6 more
core   +3 more sources

Microglia Display Altered Spatial Morphology and Proteome After Stroke

PROTEOMICS, EarlyView.
ABSTRACT Microglia are abundantly distributed throughout the central nervous system (CNS) to play critical roles in neural development and homeostasis, and act as immune sentinels to constantly monitor their surrounding neural environment. Given their high reactivity to brain insults, we hypothesised that the cerebral microenvironment altered by ...
Brooke J. Wanrooy, Jenny L. Wilson, Althea R. Suthya, Joshua H. Bourne, Joel R. Steele, Hossein Valipour Kahrood, Ralf B. Schittenhelm, Giulia Ballerin, Cameron Skinner, Shu Wen Wen, Connie H. Y. Wong   +10 more
wiley   +1 more source

SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic Organ Prolapse

Balkan Medical Journal
Background: Pelvic organ prolapse (POP) is a common gynecological chronic disorder. Human vaginal fibroblasts (HVFs) that maintain the integrity of vaginal wall tissues are essential for keeping pelvic organs in place.
Xin Jin, Qing Hu, Meiying Qin, Yitong Yin, Zhijun Xia   +4 more
doaj   +1 more source

microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling

Cancer Management and Research, 2021
Zhenkun Yan,1 Sen Hong,2 Yumei Song,3 Miaomiao Bi4 1Department of Endoscopy Center, The Third Hospital of Jilin University, Changchun, Jilin, 130022, People’s Republic of China; 2Department of Colorectal and Anal Surgery, The First Hospital of ...
Yan Z, Hong S, Song Y, Bi M
doaj