Results 91 to 100 of about 472,338 (299)

P131 | EVALUATION OF PLATELET RESPONSE IN CHRONIC ITP PATIENTS TREATED WITH A PERSONALIZED DOSING REGIMEN OF AVATROMBOPAG: A SINGLE-CENTER COHORT ANALYSIS

Haematologica
Introduction: ITP is an autoimmune disorder characterized by isolated thrombocytopenia caused by immune-mediated platelet destruction and insufficient platelet production, resulting in an increased bleeding risk. Thrombopoietin receptor agonists (TPO-RAs)
A. Baffioni, C. Giubbilei, G. Giustini, A.M. Vannucchi, V. Carrai   +4 more
doaj  

The effect of cryoprotectant on the quality of post-warming goat oocytes by examining SOD levels

Open Veterinary Journal
Background: Vitrification of oocytes can lead to the formation of reactive oxygen species during the in vitro maturation and warming processes. In this study, there is a comparison between the use of commercial cryoprotectant and ethylene glycol ...
Meisa Zalfa Adisti, Widjiati Widjiati, Agus Sunarso, Epy Muhammad Luqman, Tri Wahyu Suprayogi, Sri Pantja Madyawati, Suzanita Utama, Aulia Firmawati   +7 more
doaj   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

Zinc and Copper Levels in Patients with Primary Hypertension and Normotension [PDF]

, 2015
One of the causes of primary hypertension is an exposure to free radicals. The formation of free radicals in the body can be prevented by taking antioxidants. Zinc and copper are cofactors of endogenous antioxidant enzyme superoxide dismutase. This study
Adriani, M. (Merryana), Suryana, A. L. (Arinda), Wirjatmadi, B. (Bambang)   +2 more
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

P081 | EVALUATION OF PTPN11 MUTATION SUBTYPES AND THEIR POTENTIAL IMPACT ON CLINICAL OUTCOMES: A SINGLE-CENTER EXPERIENCE.

Haematologica
Background: PTPN11mutations can be found in 1.5%–12% of AML cases. They have been reported to cluster mainly in the N-terminal Src homology region 2 (N-SH2) and phosphatase (PTP) domains.
F. Crupi, G. Ciolli, M. Piccini, B. Scappini, L. Fasano, E. Quinti, A. Pasquini, J. Caroprese, N. Bartalucci, A. Enderti, C. Maccari, G. Rotunno, L. Signori, P. Guglielmelli, A.M. Vannucchi, F. Mannelli   +15 more
doaj  

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Efecto del estrés producido por la mezcla de sales en la concentración de aldehído malónico, proteínas y enzimas antioxidantes de Leymus chinensis de tres colores foliares diferentes [PDF]

, 2017
The mixed salt stress is common in nature. Salt stressalways affects plant growth. Different plant species have different adaptive capacity to salty soil. Leymus chinensis is an herbaceous plant with different leaf colors.
Busso, Carlos Alberto, Han, X. G., Wang, Z. W., Yang, Y. F., Yang, Y. G., Zhang, Z., Zhou, C.   +6 more
core  

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source