Results 161 to 170 of about 74,541 (281)

Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats

Experimental Physiology, EarlyView.
Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst, Iria Esperon‐Abril, Frederik Bryske Juhl, Jesper Emil Jakobsgaard, Jonas B. Kristiansen, Kristian Vissing, Tinna Stevnsner   +6 more
wiley   +1 more source

Polypyrimidine Tract-binding Protein 2 is a Potential Treated Target in Tg(SOD1*G93A)1Gur Mice [PDF]

, 2022
Zhenrong Xiong, Xinming Li, Dejiang Yang, Chongyu Xiong, Qi Zhou   +4 more
openalex   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Disulfide Scrambling Describes the Oligomer Formation of Superoxide Dismutase (SOD1) Proteins in the Familial Form of Amyotrophic Lateral Sclerosis

, 2012
Keisuke Toichi, Koji Yamanaka, Yoshiaki Furukawa   +2 more
openalex   +1 more source

Análise da influência da microglia mutante na sobrevida do neurônio motor no  modelo in vitro da esclerose lateral amiotrófica utilizando camundongos transgênicos para SOD1 humana [PDF]

, 2013
Tatiana Duobles
openalex   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Lifestyle implications of the paradox and management of oxidative stress in sperm

The Journal of Physiology, EarlyView.
Abstract figure legend Lifestyle factors influencing male fertility. Schematic overview of lifestyle factors with beneficial (left) and detrimental (right) effects on male fertility. A balanced diet, regular moderate physical activity and stress management strategies support sperm function and redox homeostasis.
Giuseppe T. Patané, Ruben J. Moreira, Annamaria Russo, Maria L. Pereira, Pedro F. Oliveira, Davide Barreca, Marco G. Alves   +6 more
wiley   +1 more source

Protein production is an early biomarker for RNA‐targeted therapies [PDF]

, 2018
Alex, Jacob, Barthélemy, Nicolas, Bateman, Randall J, Bollinger, James G, Cole, Tracy, Kordasiewicz, Holly B, Miller, Timothy M, Sato, Chihiro, Schoch, Kathleen M, Self, Wade K, Swayze, Eric   +10 more
core   +2 more sources

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1 [PDF]

, 2012
Stefania Guareschi, Emanuela Cova, Cristina Cereda, Mauro Ceroni, Elena Donetti, Daryl A. Bosco, Davide Trotti, Piera Pasinelli   +7 more
openalex   +1 more source