Results 161 to 170 of about 72,561 (329)
Nano Select, EarlyView.Polyethylene glycol‐functionalized graphene oxide (PEG‐GO) nanocomposites revolutionize nanomedicine with their high surface area and tunable properties. This review explores their synthesis, characterization, and applications in drug delivery, gene therapy, biosensing, and photothermal therapy.
Oluwasegun Chijioke Adekoya +4 more
wiley +1 more source
SOD1 Down-Regulates NF-κB and c-Myc Expression in Mice after Transient Focal Cerebral Ischemia [PDF]
, 2001 Chiung-Ying Huang +4 more
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Pediatric Discovery, EarlyView.The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu +5 more
wiley +1 more source
Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell +4 more
wiley +1 more source
The effects of human wild-type and FALS mutant L144P SOD1 on non-vascular smooth muscle contractions [PDF]
Journal of Medical Biochemistry, 2013 Background: Mutated copper, zinc-containing superoxide dismutase (SOD1) may self-aggregate, an event that could also be an initial cause of motor neuron malfunction leading to disease onset.
Nikolić-Kokić Aleksandra +6 more
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D90A-SOD1 mediated amyotrophic lateral sclerosis: A single founder for all cases with evidence for aCis-acting disease modifier in the recessive haplotype [PDF]
, 2002 M. Parton +6 more
openalex +1 more source
Aging Cell, EarlyView.We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann +16 more
wiley +1 more source
SOD1 Mutations: More to Learn [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2012 Guy A. Rouleau, Veronique V. Belzil
openaire +3 more sources
Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
Aging Cell, EarlyView.RNAi knockdown (KD) of mcu‐1 or mitoxantrone treatment lowers mitochondrial Ca2+, extends lifespan, and preserves motility during aging. Benefits require early intervention and involve a transient ROS increase that activates a pmk‐1, daf‐16, and skn‐1 pathway, enhancing stress defense and mitochondrial integrity while reducing early‐life survival ...
Doruntina Bresilla +13 more
wiley +1 more source
SOD1´s Law : An Investigation of ALS Provoking Properties in SOD1
, 2009 Proteins are the most important molecules in the cell since they take care of most of the biological functions which resemble life. To ensure that everything is working properly the cell has a rigorous control system to monitor the proper function of its proteins and sends old or dysfunctional proteins for degradation.
openaire +1 more source