Results 181 to 190 of about 74,541 (281)

The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome. [PDF]

Biol Open
Sato T, Baxter LL, Adams AD, Bishop LA, Guedj F, Bianchi DW.   +5 more
europepmc   +1 more source

Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1^−/− Mice Using Intensity, Polarization, and Spectroscopic OCT

, 2022
Conrad W. Merkle, Marco Augustin, Danielle J. Harper, Martin Glösmann, Bernhard Baumann   +4 more
openalex   +1 more source

Remote Pancreatic Response to Severe Polytrauma Correlates With Clinical Outcome

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Acute pancreatic injury can result from blunt or sharp force trauma, often leading to serious complications. While direct pancreatic trauma is associated with high rates of infection, organ failure, and mortality, little is known about the pancreas as a potential secondary target and remote trauma organ and thereby as a booster of ...
Rebecca Halbgebauer, Lisa Wohlgemuth, Jonas Wrba, Sonja Braumüller, Enes Kumral, Ludmila Lupu, Clara Morgenstern, Lucas Bettac, Sebastian Wiese, Benjamin Mayer, Paolo Cinelli, Daniel Rittirsch, Hans‐Christoph Pape, Francesco Roselli, Thomas Seufferlein, Alexander Kleger, Markus Breunig, Markus Huber‐Lang   +17 more
wiley   +1 more source

GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an Amyotrophic Lateral Sclerosis mouse model [PDF]

Didio Alberto Ortiz, Nuria Peregrín, Miguel Valencia, Rodrigo Vinueza‐Gavilanes, Elisa Marín-Ordovas, Roberto Ferrero, María Jesús Nicolás, Gloria González‐Aseguinolaza, Montserrat Arrasate, Tomás Aragón   +9 more
openalex   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Uncovering the molecular details of the 14-3-3 recruitment by mutant Sod1 species. [PDF]

Sci Rep
Di Rienzo L, Genovese I, Galluzzi G, Ruocco G, Fornetti E.   +4 more
europepmc   +1 more source

Human Skeletal Muscle Mitochondria Responses to Weight Loss Induced by Bariatric Surgery or Lifestyle Intervention

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim We investigated how weight loss induced by bariatric surgery or lifestyle intervention affects skeletal muscle mitochondrial metabolism. Methods We studied two weight‐loss cohorts: RYSA (BMI ≥ 35 kg/m2; n = 39, including 18 with diabetes) undergoing bariatric surgery, and CRYO (BMI ≥ 30 kg/m2; n = 19) undergoing a lifestyle intervention ...
Birgitta W. van der Kolk, Sini Heinonen, James W. White, Anita Wagner, Jari E. Karppinen, Sina Saari, Maheswary Muniandy, Simo Metsikkö, Eugène T. Dillon, Per‐Henrik Groop, Tuure Saarinen, Carel W. Le Roux, Kirsi A. Virtanen, Neil G. Docherty, Eija Pirinen, Anne Juuti, Kirsi H. Pietiläinen   +16 more
wiley   +1 more source

D90A-SOD1 mediated amyotrophic lateral sclerosis: A single founder for all cases with evidence for aCis-acting disease modifier in the recessive haplotype [PDF]

, 2002
M. Parton, Wendy Broom, Peter M. Andersen, Ammar Al‐Chalabi, P. Nigel Leigh, John Powell, Christopher E. Shaw   +6 more
openalex   +1 more source

Oxidative denaturation of Cu/Zn-superoxide dismutase associated with neurodegenerative diseases. [PDF]

Protein Sci
Yoshida M, Muraki N, Tajiri M, Hengphasatporn K, Sue K, Kubo T, Akashi S, Shigeta Y, Kambe T, Furukawa Y.   +9 more
europepmc   +1 more source

Evaluation of a New Methylimidazole‐Containing Thiosemicarbazone as a Cu+/Cu2+‐Targeting Ligand in the Context of Alzheimer's Disease

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
HXE modulates Cu(Aβ) interaction, reducing ROS production and shifting peptide aggregation in the presence of Cu from toxic amorphous aggregates to less harmful fibrillar structures. These findings highlight HXE potential to interfere with Cu‐induced oxidative stress and aggregation pathways relevant to AD.
Barbara Marinho Barbosa, Charlène Esmieu, Antal Galvácsi, Mariana Viana Costa, Adèle Brison, Sonia M. Ladeira, Jade de Oliveira, Csilla Kállay, Christelle Hureau, Nicolás A. Rey   +9 more
wiley   +1 more source