Results 201 to 210 of about 74,541 (281)

Development of a targeted BioPROTAC degrader selective for misfolded SOD1. [PDF]

Nat Commun
Chisholm CG, Bartlett R, Brown ML, Proctor EJ, Farrawell NE, Gorman J, Delerue F, Ittner LM, Vine-Perrow KL, Ecroyd H, Cashman NR, Saunders DN, McAlary L, Lum JS, Yerbury JJ.   +14 more
europepmc   +1 more source

Association between SOD1 Polymorphism(+35A/C) and Senile Cataract

, 2017
Maryam Sarvar Taherabadi, Alireza Nakhaee   +1 more
openalex   +1 more source

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang, Wenqian Du, Xiaojiang Zhang, Hongbo Cui, Baochen Cheng, Xiao Han, Ke He, Tingyi Yin, Xinyi Liu, Ningyi Xian, Ziyang Wang, Meng Liu, Dan Han, Jiankang Liu, Yan Zheng, Ya Wang   +15 more
wiley   +1 more source

Concurrent nanotherapeutics and regulatory updates for the management of amyotrophic lateral sclerosis: a focused review for orphan drug (Tofersen). [PDF]

Orphanet J Rare Dis
Kumar A, Shukla S, Rai A, Pathak P, Narayan KP.   +4 more
europepmc   +1 more source

In vivo self-assembled SOD1-siRNAs mitigate muscle atrophy and denervation in amyotrophic lateral sclerosis [PDF]

Jingwei Guo, Qian Zou, Jiawei Xu, Jieqiong Lei, Xin Yin, Botao Li, Jinyu Fu, Jintao Mi, Yanbo Wang, Huan Huang, Chen-Yu Zhang, Xi Chen   +11 more
openalex   +1 more source

The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL–Relish Axis in Drosophila

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu, Jiajia Fang, Dawei Cheng, Wei Luan, Yan Lv, Wen Hu, Lei Pan, Yong Zhang   +7 more
wiley   +1 more source

L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice. [PDF]

Sci Rep
Osaki T, Homma T, Maeda Y, Yamada KI, Yokoyama C, Toyokuni S, Fujii J.   +6 more
europepmc   +1 more source

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1 [PDF]

, 2014
Evangelos Kiskinis, Jackson Sandoe, Luis A. Williams, Gabriella L. Boulting, Rob Moccia, Brian J. Wainger, Steve S.W. Han, Theodore Peng, Sebastian Thams, Shravani Mikkilineni, Cassidy Mellin, Florian T. Merkle, Brandi N. Davis‐Dusenbery, Michael J. Ziller, Derek H. Oakley, Justin K. Ichida, Stefania Di Costanzo, Nick Atwater, Morgan L. Maeder, Mathew J. Goodwin, James Nemesh, Robert E. Handsaker, Daniel Paull, Scott Noggle, Steven A. McCarroll, J. Keith Joung, Clifford J. Woolf, Robert H. Brown, Kevin Eggan   +28 more
openalex   +1 more source

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source

Mitochondria-Targeted Antioxidants Prevent Tachypacing-Induced Contractile Dysfunction in In Vitro Cardiomyocyte and In Vivo <i>Drosophila</i> Models of Atrial Fibrillation. [PDF]

Antioxidants (Basel)
van Rinsum A, Hu L, Qi X, Keijer J, Zhang D.   +4 more
europepmc   +1 more source