Results 201 to 210 of about 72,561 (329)
Disulfide Bond Mediates Aggregation, Toxicity, and Ubiquitylation of Familial Amyotrophic Lateral Sclerosis-linked Mutant SOD1 [PDF]
, 2007 Jun‐ichi Niwa +8 more
openalex +1 more source
Elevated cortisol concentration in preterm sheep fetuses impacts heart development
Experimental Physiology, EarlyView.Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi +9 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber +10 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell lines with different epidermal growth factor receptor (EGFR), Kirsten rat sarcoma and tumor protein p53 ...
Yun‐Chieh Tu +10 more
wiley +1 more source
A new perspective on the role of CuZn superoxide dismutase (SOD1) [PDF]
, 2007 Paolo Mondola +3 more
openalex +1 more source
Experimental Physiology, EarlyView.Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst +6 more
wiley +1 more source
Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1–Cn protein interactions occurringin vitroandin vivo [PDF]
, 2007 Abdulbaki Aǵbaş +5 more
openalex +1 more source
Dietary nitrate supplementation mitigates age‐related changes at the neuromuscular junction in mice
The Journal of Physiology, EarlyView.Abstract figure legend Ageing is associated with a decline in muscle mass and strength, namely sarcopenia, significantly impacting the quality of life in older individuals. Different strategies are being explored to counteract these detrimental effects. In the present study, we investigated a non‐invasive nutritional approach: the impact of 2 months of
Maira Rossi +9 more
wiley +1 more source
Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons [PDF]
, 2007 Hyunjung Kim +6 more
openalex +1 more source
Antisense Oligonucleotide Therapy for Amyotrophic Lateral Sclerosis (ALS): An Umbrella Review. [PDF]
CureusJeong E, Li D.
europepmc +1 more source