Results 111 to 120 of about 221,061 (309)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Beyond sodium, phosphate and potassium: potential dietary interventions in kidney disease [PDF]

, 2017
People with kidney disease are advised to restrict individual nutrients, such as sodium, potassium, and phosphate, in line with current best practice guidelines.
Campbell, Katrina L, Johnson, David W., Jaimon T. Kelly, Megan Rossi, Katrina L. Campbell, Kelly, Jaimon T, David W. Johnson, Kelly, Jaimon T., Rossi, Megan, Campbell, Katrina L., Johnson, David W   +10 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Dietary Sodium Intake, Sweat Sodium, Salt Appetite and Exercise [PDF]

, 2015
Background: Dietary sodium intake plays an important role in the regulation of fluid and electrolyte homeostasis within the human body. Both a high sweat sodium concentration and sweat rate can induce considerable sweat sodium losses during exercise ...
Carr, Rosanna Megan
core  

Policy Options for Reducing Dietary Sodium Intake

, 2012
Faced with soaring health-care costs, Canadian governments should consider creative ways to enable the population to stay healthy — and making it possible for Canadians to reduce their sodium intake is an extremely cost-effective way to do so.
McLaren, Lindsay, Lindsay McLaren
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Sex modifies association between dietary sodium intake and cardiovascular disease mortality among US adult with hypertension: a national population-based cohort

Frontiers in Cardiovascular Medicine
ObjectivesThe objective of this study was to examine the relationship between dietary sodium intake and cardiovascular disease (CVD) mortality in hypertensive American adults.MethodsA prospective cohort study was conducted to examine the association ...
Zhiqiang Chen, Zhiqiang Chen, Jingan Rao, Weiguo Fan, Zuxiang Wu, Yumeng Shi, Yingxing Wu, Huan Hu, Xiaoshu Cheng, Ping Li   +9 more
doaj   +1 more source

Dietary effects on skin colour : appearance-based incentives to improve fruit and vegetable consumption

, 2013
Poor diet precipitates significant social and economic burden, necessitating effective and economical dietary intervention strategies. Current population-level campaigns provide guidelines for living healthily and focus on the impact of lifestyle on ...
Whitehead, Ross David
core  

Dietary sodium intake, airway responsiveness, and cellular sodium transport

, 1994
Both epidemiologic and experimental evidence suggest that a high dietary sodium intake may increase airway responsiveness, but no adequate explanation exists of how changes in sodium intake might lead to increased responsiveness.
Tribe, Rachel; id_orcid, Barton, J R, Poston, L; id_orcid, Burney, P G   +3 more
core   +1 more source