Results 1 to 10 of about 5,538 (209)

The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity [PDF]

Frontiers in Physiology, 2022
The five plasma membrane Na+/H+ exchanger (NHE) isoforms in the gastrointestinal tract are characterized by distinct cellular localization, tissue distribution, inhibitor sensitivities, and physiological regulation.
Katerina Nikolovska, Ursula E. Seidler, Christian Stock   +2 more
doaj   +2 more sources

Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney [PDF]

International Journal of Endocrinology, 2017
Previous in vitro studies demonstrated that aldosterone rapidly activates sodium-hydrogen exchangers 1 and 3 (NHE 1 and 3). In vitro investigations revealed that protein kinase C (PKC) regulates NHE properties. We previously demonstrated that aldosterone
Somchit Eiam-Ong, Mookda Chaipipat, Krissanapong Manotham, Somchai Eiam-Ong   +3 more
doaj   +2 more sources

Sodium hydrogen exchangers contribute to arenavirus cell entry. [PDF]

J Virol, 2014
ABSTRACT Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a great public health concern in the regions in which they are endemic. Moreover, evidence indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human
Iwasaki M, Ngo N, de la Torre JC.
europepmc   +4 more sources

Pulmonary endothelial cells from different vascular segments exhibit unique recovery from acidification and Na+/H+ exchanger isoform expression

PLoS ONE, 2022
Sodium-hydrogen exchangers (NHEs) tightly regulate intracellular pH (pHi), proliferation, migration and cell volume. Heterogeneity exists between pulmonary endothelial cells derived from different vascular segments, yet the activity and isoform ...
Dylan Adams, Chung-Sik Choi, Sarah L. Sayner   +2 more
doaj   +2 more sources

A soybean sodium/hydrogen exchanger GmNHX6 confers plant alkaline salt tolerance by regulating Na+/K+ homeostasis

Frontiers in Plant Science, 2022
Alkaline soil has a high pH due to carbonate salts and usually causes more detrimental effects on crop growth than saline soil. Sodium hydrogen exchangers (NHXs) are pivotal regulators of cellular Na+/K+ and pH homeostasis, which is essential for salt ...
Ting Jin, Jiaxin An, Huadong Xu, Jie Chen, Lang Pan, Ranran Zhao, Ning Wang, Junyi Gai, Yan Li   +8 more
doaj   +1 more source

Cognitive Sequelae and Hippocampal Dysfunction in Chronic Kidney Disease following 5/6 Nephrectomy

Brain Sciences, 2022
Neurological disorders are prevalent in patients with chronic kidney disease (CKD). Vascular factors and uremic toxins are involved with cognitive impairment in CKD.
Yeon Hee Yu, Seong-Wook Kim, Hyuna Im, Se Won Oh, Nam-Jun Cho, Samel Park, Dae-Kyoon Park, Duk-Soo Kim, Hyo-Wook Gil   +8 more
doaj   +1 more source

Sodium/hydrogen‐exchanger‐2 modulates colonocyte lineage differentiation [PDF]

Acta Physiologica, 2022
AbstractAimThe sodium/hydrogen exchanger 2 (NHE2) is an intestinal acid extruder with crypt‐predominant localization and unresolved physiological significance. Our aim was to decipher its role in colonic epithelial cell proliferation, differentiation and electrolyte transport.MethodsAlterations induced by NHE2‐deficiency were addressed in murine nhe2−/−
Katerina Nikolovska, Li Cao, Inga Hensel, Gabriella Di Stefano, Anna Elisabeth Seidler, Kunyan Zhou, Jiajie Qian, Anurag Kumar Singh, Brigitte Riederer, Ursula Seidler   +9 more
openaire   +2 more sources

Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model

Journal of Virus Eradication, 2022
Because of rapid emergence and circulation of the SARS-CoV-2 variants, especially Omicron which shows increased transmissibility and resistant to antibodies, there is an urgent need to develop novel therapeutic drugs to treat COVID-19.
Yukinori Endo, Brady T. Hickerson, Natalia A. Ilyushina, Nishant Mohan, Hanjing Peng, Kazuyo Takeda, Raymond P. Donnelly, Wen Jin Wu   +7 more
doaj   +1 more source

Regulation of Na+/H+ exchangers, Na+/K+ transporters, and lignin biosynthesis genes, along with lignin accumulation, sodium extrusion, and antioxidant defense, confers salt tolerance in alfalfa

Frontiers in Plant Science, 2022
Accumulation of high sodium (Na+) leads to disruption of metabolic processes and decline in plant growth and productivity. Therefore, this study was undertaken to clarify how Na+/H+ exchangers and Na+/K+ transporter genes contribute to Na+ homeostasis ...
Md Atikur Rahman, Jae Hoon Woo, Sang-Hoon Lee, Hyung Soo Park, Ahmad Humayan Kabir, Ahmad Humayan Kabir, Ali Raza, Ayman El Sabagh, Ayman El Sabagh, Ki-Won Lee   +9 more
doaj   +1 more source

Oncogenic RAS drives the CRAF‐dependent extracellular vesicle uptake mechanism coupled with metastasis

Journal of Extracellular Vesicles, 2021
Oncogenic RAS impacts communication between cancer cells and their microenvironment, but it is unclear how this process influences cellular interactions with extracellular vesicles (EVs). This is important as intercellular EV trafficking plays a key role
Dongsic Choi, Laura Montermini, Brian Meehan, Anthoula Lazaris, Peter Metrakos, Janusz Rak   +5 more
doaj   +1 more source