Results 131 to 140 of about 5,538 (209)

Massive Activation of GABA_A Receptors: Rundown, Ionic and Neurodegenerative Consequences. [PDF]

Biomolecules
Menzikov SA, Zaichenko DM, Moskovtsev AA, Morozov SG, Kubatiev AA.   +4 more
europepmc   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source

PIP₂-mediated oligomerization of the endosomal sodium/proton exchanger NHE9. [PDF]

Nat Commun
Kokane S, Gulati A, Meier PF, Matsuoka R, Pipatpolkai T, Albano G, Ho TM, Delemotte L, Fuster D, Drew D.   +9 more
europepmc   +1 more source

Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods. [PDF]

Proc Natl Acad Sci U S A, 2004
Fuster D, Moe OW, Hilgemann DW.
europepmc   +1 more source

Boosting Photo‐Pyroelectric Effect via Tunable Polarization and Interfacial Defect Engineering

Advanced Science, EarlyView.
This study reports Ba(Ti0.85Zr0.15)O3 nanocatalysts with enhanced polarization and oxygen‐vacancy‐rich interfaces for efficient NIR‐II photo‐pyroelectric therapy. Zr doping boosts the pyroelectric coefficient and accelerates polarization switching, while oxygen vacancies improve photothermal conversion and surface reactivity.
Yanli Huang, Haifen Luo, Jie Yin, Shuai Cao, Gaolei Dong, Zhi Tan, Chunlin Zhao, Peiye Wen, Fengwei Sun, Shan Zhang, Xianzeng Zhang, Yunlu Dai, Zhen Yang, Wei Huang   +13 more
wiley   +1 more source

Glauber's Salt Composites for HVAC Applications: A Study on the Use of the T-History Method with a Modified Data Evaluation Methodology. [PDF]

Materials (Basel)
Ayyagari V, Shooshtari A, Ohadi M.
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism. [PDF]

Ann Med
Wu Q, Qiu X, Chen H.
europepmc   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Assessing Molecular Mechanisms of Stress Induced Salinity Adaptation in the Juvenile Ornate Spiny Lobster, <i>Panulirus ornatus</i>. [PDF]

Int J Mol Sci
Spencer EL, Fitzgibbon QP, Glendinning S, Lewis CL, Banks TM, Trotter AJ, Ventura T, Smith GG.   +7 more
europepmc   +1 more source