Results 261 to 270 of about 23,359 (316)

Druggability of Sodium Calcium Exchanger (NCX): Challenges and Recent Development. [PDF]

open access: yesInt J Mol Sci
Scognamiglio A   +6 more
europepmc   +1 more source

Implications of sodium hydrogen exchangers in various brain diseases

Journal of Basic and Clinical Physiology and Pharmacology, 2015
Abstract Na+/H+ exchangers (NHEs) are the transporter proteins that play an important role in intracellular pH (pHi) regulation, cell differentiation and cell volume and that mediate transepithelial Na+ and HCO3 − absorption on the basis of chemical gradients across the plasma membrane. Its activation causes an increase
Vivek, Verma   +3 more
openaire   +4 more sources

An avian sodium-hydrogen exchanger

Comparative Biochemistry and Physiology Part A: Physiology, 1997
Intestinal sodium transporters, such as the Na+/H+ exchanger (NHE) are important for Na+ conservation in land birds. In mammals, at least five isoforms of the exchanger, NHEs 1-5, have been cloned, with NHE-1 occurring in epithelial basolateral and nonepithelial cell membranes and NHE-3 being restricted to epithelial apical/brush border membranes.
S G, Bhartur   +5 more
openaire   +2 more sources

Seizures and Sodium Hydrogen Exchangers: Potential of Sodium Hydrogen Exchanger Inhibitors as Novel Anticonvulsants

CNS & Neurological Disorders - Drug Targets, 2008
Advances in the understanding of mechanisms underlying the pathophysiology of epilepsy have led to the identification of sodium hydrogen exchanger (NHE) as one of the possible targets for future antiepileptic drugs (AEDs). There are indicators from several experimental studies that NHE inhibitors could be of significant value as potential ...
A, Ali   +4 more
openaire   +2 more sources

ERYTHROCYTE SODIUM/HYDROGEN EXCHANGE INHIBITION BY (−) EPICATECHIN

Cell Biology International, 2001
Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin‐like properties. Besides their anti‐diabetic properties, catechins also show growth inhibition. Since cytosolic pH (pHi) plays a role in cell proliferation and the Na/H exchanger (NHE) is the major pH (pHi) regulatory ...
MATTEUCCI, ELENA   +2 more
openaire   +3 more sources

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